{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:03:48Z","timestamp":1790309028470,"version":"4.1.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The clinical utility of the polygenic risk score in predicting cardiovascular events in patients with atrial fibrillation (AF) has not yet been established. This study aimed to determine whether the polygenic risk score for AF might be useful in the risk stratification of AF\u2010related cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This study included 9597 oral anticoagulation\u2013naive patients with AF with a CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VA (congestive heart failure; hypertension; age \u226575\u2009years; diabetes; prior\u00a0stroke or transient ischemic attack or thromboembolism; vascular disease; and age 65\u201374\u2009years) score of 0 or 1 from the UK Biobank. Patients were stratified according to polygenic risk score tertiles and observed for the occurrence of ischemic stroke or systemic embolism, myocardial infarction, and heart failure hospitalization. The risks of incident events associated with the polygenic risk score were investigated using inverse probability of treatment weighting. Of 9597 individuals, 3800 (39.6%) were women and the mean\u00b1SD age was 65.3\u00b16.4\u2009years. During a median follow\u2010up of 4.6\u2009years (interquartile range, 1.7\u20137.9\u2009years), the incidence rates of ischemic stroke or systemic embolism, myocardial infarction, and heart failure hospitalization were 0.83, 0.42, and 0.61 per 100 person\u2010years, respectively. Compared with low genetic risk, high genetic risk was associated with a hazard ratio of 1.38 (95% CI, 1.08\u20131.76;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.011) for ischemic stroke or systemic embolism, 1.15 (95% CI, 0.82\u20131.61;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.422) for myocardial infarction, and 1.02 (95% CI, 0.78\u20131.34;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.895) for heart failure hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with AF with low\u2013intermediate stroke risk, genetic risk for AF is associated with increased risk of stroke or systemic embolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037727","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T23:50:11Z","timestamp":1742601011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk"],"prefix":"10.1161","volume":"14","author":[{"given":"Juntae","family":"Kim","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Dankook University College of Medicine","place":["Chungnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-4365","authenticated-orcid":false,"given":"Dongmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Dankook University College of Medicine","place":["Chungnam, Republic of 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