{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:05:06Z","timestamp":1789005906684,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Tricuspid regurgitation (TR) severity is associated with poor prognosis in patients with atrial fibrillation (AF). Recently, right ventricular\u2013pulmonary arterial (RV\u2010PA) coupling has been shown to be related to clinical outcomes in patients with TR. However, data on the relationship of RV\u2010PA coupling to the progression of significant TR are limited. This study aimed to investigate whether RV\u2010PA coupling affects the progression of significant TR in patients with AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Among 664 patients with AF who underwent follow\u2010up echocardiography at least 6 months after the initial assessment, 484 consecutive patients with AF (mean age 68\u00b112\u2009years, 38% women) with insignificant TR were included. RV\u2010PA coupling was assessed by the ratio of RV 4\u2010chamber strain measured through speckle tracking echocardiography to pulmonary artery systolic pressure (PASP).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Over a mean 3.6\u00b12.7\u2009years of follow\u2010up, 46 (9.5%) patients have progressed to significant TR, at least a moderate degree. Patients who progressed to significant TR were older, more likely to be women, had higher E\/e\ua78b and PASP, lower RV4CSL and RV 4\u2010chamber strain \/PASP compared with patients without TR progression. RV\u2010PA coupling, reflected by RV 4\u2010chamber strain\/PASP, was independently associated with the progression of TR even after adjusting for age, sex, and E\/e\ua78b (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). It remained significant for predicting TR progression even after further adjustment for PASP or RV strain (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with AF, RV\u2010PA coupling was independently associated with the progression of TR, suggesting that it may be helpful in monitoring this population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037757","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:39:48Z","timestamp":1741862388000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Right Ventricular\u2013Pulmonary Arterial Coupling and Progression of Tricuspid Regurgitation in Patients With Atrial Fibrillation"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-6083","authenticated-orcid":false,"given":"Dae\u2010Young","family":"Kim","sequence":"first","affiliation":[{"name":"Inha University College of Medicine","place":["Incheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kee","family":"Ryu","sequence":"additional","affiliation":[{"name":"Ewha Womans University Medical Center","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hun","family":"Jang","sequence":"additional","affiliation":[{"name":"Inha University College of Medicine","place":["Incheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1189-4701","authenticated-orcid":false,"given":"Hye\u2010Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Inha University","place":["Incheon, South 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South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-6279","authenticated-orcid":false,"given":"Seong\u2010Ill","family":"Woo","sequence":"additional","affiliation":[{"name":"Inha University College of Medicine","place":["Incheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-7866","authenticated-orcid":false,"given":"Dae\u2010Hyeok","family":"Kim","sequence":"additional","affiliation":[{"name":"Inha University College of Medicine","place":["Incheon, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-9622","authenticated-orcid":false,"given":"Sung\u2010Hee","family":"Shin","sequence":"additional","affiliation":[{"name":"Inha University College of Medicine","place":["Incheon, South 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