{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:14Z","timestamp":1791942434306,"version":"4.3.4"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Systemic inflammation, aging, and type 2 diabetes (T2D) lead to varying degrees of cardiovascular dysfunction and impaired aerobic exercise capacity. This study evaluates the impact of inflammation and sex differences on coronary and peripheral vascular function and exercise capacity in older individuals with and without T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Older individuals (aged\u226565\u2009years) underwent biochemical and tissue inflammatory phenotyping, cardiopulmonary exercise testing, cardiovascular magnetic resonance imaging, and vascular reactivity testing. Correlation and regression analyses determined the effects of systemic inflammation, older age, and sex on cardiovascular health, stratified by T2D status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      For the 133 recruited individuals (44% women; median age, 71\u00b17\u2009years, 41% with T2D), the presence of T2D most significantly increased the white blood cell count (\n                      <jats:italic>P<\/jats:italic>\n                      =0.004;\n                      <jats:italic>P<\/jats:italic>\n                      .adj.=0.140) among markers of systemic inflammation. White blood cell count was comparable in men and women. Hyperemic myocardial blood flow and flow\u2010mediated and flow\u2010independent nitroglycerin\u2013induced brachial artery dilation were significantly impaired in men but not women with T2D. Peak oxygen consumption during exercise was lower with T2D (\n                      <jats:italic>P<\/jats:italic>\n                      =0.021), and overall reduced in women compared with men (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002). Across all participants, both peak oxygen consumption during exercise and hyperemic myocardial blood flow were significantly impaired with increased white blood cell count. Women showed more adverse myocardial remodeling assessed by extracellular volume than men (\n                      <jats:italic>P<\/jats:italic>\n                      =0.008), independently of T2D status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The pathophysiological manifestations of T2D on vascular function and aerobic exercise capacity are distinct in older men and women, and this may reflect underlying differences in vascular and myocardial aging in the presence of T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037863","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:13:19Z","timestamp":1737612799000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Age and Sex on Systemic Inflammation and Cardiometabolic Function in Individuals With Type 2 Diabetes"],"prefix":"10.1161","volume":"14","author":[{"given":"Jody","family":"Dushay","sequence":"first","affiliation":[{"name":"Division of Endocrinology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-0719","authenticated-orcid":false,"given":"Eva S.","family":"Rickers","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"},{"name":"Medical Faculty University of Cologne, and Department of Neurology, University Hospital Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-7780","authenticated-orcid":false,"given":"Enya","family":"Wang","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Gilman","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA"},{"name":"Currently at Department of Endocrinology The Third People\u2019s Hospital of Shenzhen Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-6562","authenticated-orcid":false,"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Division of Cardiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest V.","family":"Gervino","sequence":"additional","affiliation":[{"name":"Division of Cardiology Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-6731","authenticated-orcid":false,"given":"Michael","family":"Jerosch\u2010Herold","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham and Women\u2019s Hospital, Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3901-4405","authenticated-orcid":false,"given":"Aristidis","family":"Veves","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Center for Regenerative Therapeutics, Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504347"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30314-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809798"},{"key":"e_1_3_1_5_2","first-page":"197","article-title":"Canakinumab for atherosclerotic disease","volume":"378","author":"Rothman AM","year":"2018","unstructured":"Rothman AM, Morton AC, Crossman DC; MRC\u2010ILA heart investigators . Canakinumab for atherosclerotic disease. N Engl J Med. 2018;378:197\u2013198.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311378"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.07802"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0324"},{"key":"e_1_3_1_9_2","first-page":"421","article-title":"Aging and the cardiovascular system","volume":"51","author":"Karavidas A","year":"2010","unstructured":"Karavidas A, Lazaros G, Tsiachris D, Pyrgakis V. Aging and the cardiovascular system. Hell J Cardiol. 2010;51:421\u2013427.","journal-title":"Hell J Cardiol"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0650"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/914057"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000912"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.12.026"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00066-2"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0150-0"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2230"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12389-6"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.959437"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02164-2"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn350"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826fb946"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01746-6"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.193"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X08098273"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201905-378OC"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00722.2014"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.914788"},{"key":"e_1_3_1_29_2","volume-title":"Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications","author":"Wasserman K","year":"2011","unstructured":"Wasserman K, Hansen J, Sue D, Stringer BW, Sietsema K, Sun X, Whipp BJ. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications. 5th ed. Wolters Kluwer Health; 2011.","edition":"5"},{"key":"e_1_3_1_30_2","volume-title":"An R Companion to Applied Regression","author":"Fox J","year":"2019","unstructured":"Fox J, Weisberg S. An R Companion to Applied Regression. 3rd ed. LosAngeles: Sage Publications, Inc.; 2019.","edition":"3"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01804-9"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2329"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S51301"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160998"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67196-y"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.036"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(02)00147-3"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043430"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002407"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-1213-1"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.07.013"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1202.105290"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00859.2013"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1846"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006713"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003769"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312289"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2415"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0602"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604558113"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051231"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2019.03.001"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01842-3"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70848-8"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1911-y"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0188"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0227"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz486"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00203-5"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2015-000185"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.037863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T06:02:47Z","timestamp":1738648967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.037863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,4]]}},"alternative-id":["10.1161\/JAHA.124.037863"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.037863","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.08.24307092","asserted-by":"object"}]},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e037863"}}