{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:47:27Z","timestamp":1792075647512,"version":"4.4.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Obesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy and safety of bempedoic acid in people with obesity participating in the CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACL\u2010Inhibiting Regimen) Outcomes trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              CLEAR Outcomes randomized 13\u2009970 patients to daily bempedoic acid 180\u2009mg or placebo. Exploratory outcomes including major adverse cardiovascular events\u20104 (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization), low\u2010density lipoprotein cholesterol, hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein), weight change, and safety were assessed over a median of 40.7\u2009months in 6177 patients with baseline body mass index \u226530\u2009kg\/m\n              <jats:sup>2<\/jats:sup>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In people with obesity, bempedoic acid resulted in placebo\u2010corrected reductions in low\u2010density lipoprotein cholesterol of \u221222.5% and hs\u2010CRP of \u221223.2% at 6\u2009months. Bempedoic acid treatment resulted in a major adverse cardiovascular events\u20104 reduction of 23% (hazard ratio [HR], 0.77 [95% CI, 0.67\u20130.89]) versus placebo. Nonfatal and fatal MI were reduced by 32% (HR, 0.68 [95% CI, 0.53\u20130.86]), coronary revascularization was reduced by 24% (HR, 0.76 [95% CI, 0.63\u20130.92]), and fatal and nonfatal stroke were reduced by 36% (HR, 0.64 [95% CI, 0.45\u20130.89]) compared with placebo. At month 36, mean\u00b1SD change in weight from baseline was \u22122.3 (6.3) kg for bempedoic acid and \u22121.4 (6.1) kg for placebo. Adverse events were reported in 87.4% of bempedoic acid patients and 86.7% of placebo patients. The mean\u00b1SD change in uric acid at 6\u2009months was 0.81 (1.26) mg\/dL for bempedoic acid versus \u22120.04 (1.05) mg\/dL for placebo.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among people with obesity, bempedoic acid reduced major adverse cardiovascular events, low\u2010density lipoprotein cholesterol, and hs\u2010CRP, with a safety profile consistent with previous reports.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique Identifier: NCT02993406.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.037898","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T10:33:51Z","timestamp":1739010831000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-1408","authenticated-orcid":false,"given":"Harold E.","family":"Bays","sequence":"first","affiliation":[{"name":"Louisville Metabolic and Atherosclerosis Research Center Louisville KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeAnne","family":"Bloedon","sequence":"additional","affiliation":[{"name":"Esperion Therapeutics, Inc. 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Michael","family":"Lincoff","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Victorian Heart Institute Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-9876","authenticated-orcid":false,"given":"Jorge","family":"Plutzky","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Powell","sequence":"additional","affiliation":[{"name":"Esperion Therapeutics, Inc. 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