{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:08:48Z","timestamp":1792642128536,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">There is no evidence evaluating efficiency, effectiveness, and safety outcomes in older patients in the context of pulsed\u2010field ablation technology for the ablation of atrial fibrillation. We aimed to compare safety, efficacy, and acute and long\u2010term outcomes of pulsed\u2010field ablation in older patients (\u226575\u2009years) with younger ones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We enrolled consecutive patients who had undergone atrial fibrillation ablation with the pulsed\u2010field ablation FARAPULSE system (Boston Scientific) at 15 centers. Patients were stratified by age (&lt;65, 65\u201374, and \u226575\u2009years) and efficacy and safety profiles of these groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 1082 patients were included: 108 (10%) were \u226575\u2009years old, 374 (34.6%) were 65\u201374\u2009years old and 600 (55.4%) were &lt;65\u2009years old. Older patients displayed a more pronounced risk profile compared with their younger counterparts, characterized by a significant higher burden of comorbidities. No differences in terms of procedural metrics were found. Pulmonary vein isolation was achieved in all patients. An overall low rate of procedural\u2010related complications was reported (3.0%) without difference between young and older patients (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.241). During a mean follow\u2010up of 342\u00b1111\u2009days, a primary efficacy end point occurred in 605 of 748 (80.9%) patients with available outcome information. The arrhythmia recurrence rate ranged from 14.4% in patients &lt;65\u2009years old to 26.9% of older patients (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Drawing from these findings, using the FARAPULSE system for atrial fibrillation ablation in older patients demonstrated swift, safe, and effective acute outcomes, mirroring a comparable pattern observed in younger patients and recurrence rates in line with the literature in older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT05617456.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.037959","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:54:57Z","timestamp":1745391297000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Does Age Impact Safety and Efficacy During Pulse\u2010Field Ablation for Atrial Fibrillation?"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-421X","authenticated-orcid":false,"given":"Antonio","family":"Dello Russo","sequence":"first","affiliation":[{"name":"Marche Polytechnic University","place":["Ancona, Italy"]},{"name":"Marche University Hospital","place":["Ancona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-8313","authenticated-orcid":false,"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[{"name":"Monzino Cardiological Center","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-8105","authenticated-orcid":false,"given":"Stefano","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Ospedale Isola Tiberina \u2010 Gemelli Isola","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-2583","authenticated-orcid":false,"given":"Vincenzo","family":"Schillaci","sequence":"additional","affiliation":[{"name":"Montevergine Clinic","place":["Mercogliano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research","place":["Cotignola, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5322-1742","authenticated-orcid":false,"given":"Michela","family":"Casella","sequence":"additional","affiliation":[{"name":"Marche University Hospital","place":["Ancona, Italy"]},{"name":"Marche Polytechnic University","place":["Ancona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rossillo","sequence":"additional","affiliation":[{"name":"San Bortolo Hospital","place":["Vicenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"Maggio","sequence":"additional","affiliation":[{"name":"Degli Infermi Hospital","place":["Rivoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-7113","authenticated-orcid":false,"given":"Sakis","family":"Themistoclakis","sequence":"additional","affiliation":[{"name":"Dell\u2019Angelo Hospital","place":["Mestre, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-7140","authenticated-orcid":false,"given":"Matteo","family":"Bertini","sequence":"additional","affiliation":[{"name":"Sant\u2019Anna University Hospital","place":["Ferrara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Russo","sequence":"additional","affiliation":[{"name":"San Filippo Neri Hospital","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Volpicelli","sequence":"additional","affiliation":[{"name":"S. Maria della Piet\u00e0 Hospital","place":["Nola, Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7185-9582","authenticated-orcid":false,"given":"Graziana","family":"Viola","sequence":"additional","affiliation":[{"name":"University Hospital","place":["Sassari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4111-1690","authenticated-orcid":false,"given":"Roberto","family":"Rordorf","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico San Matteo","place":["Pavia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-3380","authenticated-orcid":false,"given":"Marco","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Monzino Cardiological Center","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-0739","authenticated-orcid":false,"given":"Yari","family":"Valeri","sequence":"additional","affiliation":[{"name":"Marche University Hospital","place":["Ancona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Colella","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care & Research","place":["Cotignola, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8930-5609","authenticated-orcid":false,"given":"Pietro","family":"Rossi","sequence":"additional","affiliation":[{"name":"Ospedale Isola Tiberina \u2010 Gemelli Isola","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-535X","authenticated-orcid":false,"given":"Fabrizio","family":"Tundo","sequence":"additional","affiliation":[{"name":"Monzino Cardiological Center","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Zingarini","sequence":"additional","affiliation":[{"name":"S. 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