{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:06:13Z","timestamp":1779793573373,"version":"3.53.1"},"reference-count":95,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Dilated cardiomyopathy (DCM) is a severe form of cardiomyopathy. The study aims to investigate the impact of metabolic and lifestyle factors on DCM and to identify new potential therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Both bidirectional Mendelian randomization (MR) and Bayesian colocalization were performed based on summary data from large\u2010scale, genome\u2010wide association studies and the FinnGen project. Single nucleotide variant strongly associated with exposure at the genome\u2010wide significance level were\u00a0used as instrumental variables. Methods of inverse\u2010variance weighted, debiased inverse\u2010variance weighted, weighted median, weighted mode, MR\u2010Egger, robust\u2010adjusted profile score, contamination mixture, and constrained maximum likelihood and model averaging were used to validate the robustness of the MR results and the level of multiplicity. Summary\u2010data\u2010based MR was used for the analysis of potential drug targets of DCM using data of cis\u2010expression quantitative trait loci and cis\u2010protein quantitative trait loci. Steiger filtering and Bayesian colocalization were employed for reverse causality detection to further consolidate the MR findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This study found that genetically predicted systolic blood pressure, hypertension, basal metabolic rate, waist circumference, body mass index, and hip circumference were associated with an increased risk of DCM. The inverse\u2010variance weighted estimate showed that sleep duration and never smoking were protective factors against DCM. The summary\u2010data\u2010based MR analysis revealed 11 potential candidate genetic variants and risk genes associated with DCM. Among them,\n                      <jats:italic toggle=\"no\">SEMA7A<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"no\">ETFA<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"no\">CNTFR<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"no\">TGM2<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"no\">GOLGB1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"no\">DNAJB12<\/jats:italic>\n                      were associated with a decreased risk of DCM. Colocalization analysis indicated that the expression quantitative trait loci signals of\n                      <jats:italic toggle=\"no\">SLC9B1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"no\">TGM2<\/jats:italic>\n                      share causal variants with the risk of DCM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study supports independent causal roles of systolic blood pressure, hypertension, waist circumference, hip circumference, body mass index, basal metabolic rate, sleep duration, and never smoking in DCM. We also identified several potential candidate variants and risk genes involved in the genetic basis of DCM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038088","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T10:22:07Z","timestamp":1767090127000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Risk Factors and Therapeutic Targets for Dilated Cardiomyopathy Identified Through Mendelian Randomization Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2522-6850","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-5557","authenticated-orcid":false,"given":"Yihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2428-8786","authenticated-orcid":false,"given":"Dezhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1607-3004","authenticated-orcid":false,"given":"Caiyun","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3972-8471","authenticated-orcid":false,"given":"Xuting","family":"Xia","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0182-245X","authenticated-orcid":false,"given":"Guichun","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1416-5070","authenticated-orcid":false,"given":"Jianchen","family":"Shi","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4441-037X","authenticated-orcid":false,"given":"Xinhui","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]},{"name":"Hunan University of Chinese Medicine","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.80.3.564"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001123"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01241-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000455"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01505-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.08.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.033"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.112.000120"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199902253400804"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.12.012"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309711"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad736"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3314"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00931-x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_3_2_19_2","volume-title":"MRC IEU UK Biobank GWAS Pipeline Version 2","author":"Mitchell R","year":"2019","unstructured":"Mitchell R, Elsworth BL, Raistrick CA, Paternoster L, Hemani G, Gaunt TR. 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