{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:03:13Z","timestamp":1789711393070,"version":"4.0.1"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Preeclampsia is a risk factor for the development of later\u2010life cardiovascular disease. However, the underlying mechanisms are poorly understood. Excessive hypercholesteremia in pregnancy induces a preeclampsia\u2010like phenotype, but whether this also impacts maternal vascular function later in life has not been fully characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sprague Dawley rats received a control diet (CD) or a high\u2010cholesterol (HCD) diet from gestational day 6 to 20, after which maternal vascular function was assessed 3\u2009months postpartum. Exposure to an HCD in pregnancy reduced later\u2010life endothelium\u2010dependent vasodilation in carotid arteries (\u221215.24\u00b13.27%), which was mediated via prostaglandin H synthase 2. There were no differences in vasodilation between CD and HCD postpartum rats in the mesenteric arteries, coronary arteries, or aortas. Vasoconstriction to phenylephrine increased in carotid arteries (61.02\u00b121.48%) and reduced in aortas (\u221223.24\u00b16.19%) of the HCD postpartum group versus CD dams, without differences in mesenteric and coronary arteries. The increased vasoconstriction in carotid arteries was due to lower nitric oxide modulation of constriction. Moreover, carotid artery myogenic response was reduced (\u221237.68\u00b110.07%) and stiffness was increased (19.67\u00b16.21%) in the HCD postpartum rats compared with CD along with decreased elastin density (\u221220.85\u00b14.52%). The impact of the HCD on vascular function did not occur in age\u2010matched never\u2010pregnant female rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Excessive hypercholesterolemia in pregnancy impairs later\u2010life maternal vascular function in rats with varying impacts across different vascular beds. Understanding mechanisms for\n                      <jats:italic toggle=\"no\">pregnancy\u2010specific<\/jats:italic>\n                      excessive hypercholesterolemia provides avenues for targeted intervention strategies to reduce the burden of cardiovascular disease in women who had a complicated pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038123","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T06:57:24Z","timestamp":1740466644000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Excessive Hypercholesterolemia in Pregnancy Impairs Later\u2010Life Maternal Vascular Function in Rats"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-4297","authenticated-orcid":false,"given":"Amanda A.","family":"de Oliveira","sequence":"first","affiliation":[{"name":"University of 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