{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:49Z","timestamp":1788876589016,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Stent implantation poses challenges in small children due to their limited vessel size and rapid growth. This multicenter study evaluates in\u00a0vivo efficacy of implanting Optimus\u2010L stents in small patients using a low\u2010profile approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively reviewed data from children weighing \u226420 kg with congenital heart stenotic lesions who received Optimus\u2010L stents manually mounted on small\u2010sized balloon catheters (diameter \u226412\u2009mm) using a hand\u2010actuated compression tool and implanted through small\u2010sized sheaths (\u22648 Fr) at our institutions between May 2022 and January 2024. Stent performance was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We identified 28 patients (67.8% male) with median age and weight of 3.4\u2009years (interquartile range [IQR], 1.5\u20135.5) and 12.9 kg (IQR, 9.1\u201316.4). Six (21.4%) were infants, 11 (39.3%) \u226410 kg. Stenotic lesions included 16 branch pulmonary arteries, 9 aortic isthmus, 2 right ventricular outflow tracts, and 1 Glenn anastomosis. Percentage of stenosis was 50% (IQR, 36%\u201358%). All implantations were successful without complications. The procedures mostly used 7 Fr sheaths for stents on 6, 7, and 8\u2009mm balloons and 8 Fr sheaths for 9, 10, 12\u2009mm balloons. Median stent expansion percentage was 95% (IQR, 90%\u201396%). Median vessel diameters increased from 4.6\u2009mm (IQR, 3.8\u20135.1) to 8.8 mm (IQR, 7.5\u20139.5) (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), with median stenosis expansion at 103% (IQR, 51%\u2013146%). Median stent shortening was 1.9% (IQR, 0%\u20133.9%). Two patients required redo stent balloon dilation after 18 and 20 months. Median follow\u2010up was 8 months (IQR, 3.2\u201313.2). Median last recorded Doppler velocity on implanted stents was 1.6 m\/s (IQR, 1.2\u20132).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Optimus\u2010L stents can safely treat arterial and venous stenosis in infants and small children via a low\u2010profile approach with good outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038301","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:07:58Z","timestamp":1740550078000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["OPTILOW: A Low\u2010Profile Approach for Implanting Optimus\u2010L Stents in Infants and Children"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-3550","authenticated-orcid":false,"given":"Katarzyna","family":"Gendera","sequence":"first","affiliation":[{"name":"Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-1316","authenticated-orcid":false,"given":"James R.","family":"Bentham","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Trust","place":["Leeds, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-8160","authenticated-orcid":false,"given":"Stanimir","family":"Georgiev","sequence":"additional","affiliation":[{"name":"Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kasem","sequence":"additional","affiliation":[{"name":"Al Jalila Children\u2019s Speciality Hospital","place":["Dubai, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-1190","authenticated-orcid":false,"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[{"name":"Technical University of Munich","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-4724","authenticated-orcid":false,"given":"J\u00f6rg","family":"Michel","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tuebingen","place":["Tuebingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-4708","authenticated-orcid":false,"given":"Raymond N.","family":"Haddad","sequence":"additional","affiliation":[{"name":"M3C\u2010Necker, Necker\u2010Enfants Malades University Hospital, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP\u2010HP)","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2018.08.005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21009"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15916"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.74.6.689"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1466-8"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25908"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.051"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29706"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951123000720"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25543"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111500219X"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003281"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.09.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.11.008"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2022-002157"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02363-6"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2020.685"},{"key":"e_1_3_1_19_2","first-page":"524","article-title":"Defective limb growth as a complication of catheterization of the femoral artery","volume":"138","author":"Bloom JD","year":"1974","unstructured":"Bloom JD, Mozersky DJ, Buckley CJ, Hagood CO Jr. Defective limb growth as a complication of catheterization of the femoral artery. 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