{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:13:25Z","timestamp":1781187205438,"version":"3.54.1"},"reference-count":95,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:p xml:lang=\"en\">Inherited cardiac channelopathies are linked to a heightened risk of sudden cardiac death. Despite evolving knowledge on different genes for these inherited conditions, for certain subtypes, such as catecholaminergic polymorphic ventricular tachycardia syndrome, the specific genetic causes remain unidentified. The research of the pathophysiological mechanisms underlying catecholaminergic polymorphic ventricular tachycardia syndrome has been conducted through different in\u00a0vitro and in\u00a0vivo models, including genetically modified animal models, cardiac\u2010specific transgenic models, pharmacological interventions in animal models, human\u2010induced pluripotent stem cell\u2013derived cardiomyocytes in 2\u2010 and 3\u2010dimensional cardiac models. Recent research predominantly utilizes human\u2010induced pluripotent stem cell\u2013derived cardiomyocytes, focusing on genotype\u2013phenotype correlations and pharmacological screening. The integration of cutting\u2010edge techniques such as clustered regularly interspaced short palindromic repeats\/Cas9 genome editing and 3\u2010dimensional\u2013engineered heart tissues has shed new light on the pathophysiological mechanisms of catecholaminergic polymorphic ventricular tachycardia, potentially enhancing drug therapies as part of personalized medicine approaches. This review emphasizes the diverse insights gained from both in\u00a0vivo and in\u00a0vitro studies of catecholaminergic polymorphic ventricular tachycardia, along with the application of these models in various research contexts.<\/jats:p>","DOI":"10.1161\/jaha.124.038308","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:31:51Z","timestamp":1741861911000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9612-7574","authenticated-orcid":false,"given":"Luca","family":"Schneider","sequence":"first","affiliation":[{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5434-1374","authenticated-orcid":false,"given":"Merima","family":"Begovic","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-0127","authenticated-orcid":false,"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Mannheim, Germany"]},{"name":"Institute of Cardiovascular Research, Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-0008","authenticated-orcid":false,"given":"Nazha","family":"Hamdani","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"Cardiovascular Research Institute, University Maastricht","place":["Maastricht, The Netherlands"]},{"name":"Int\u00e9zet c\u00edme Semmelweis University","place":["Budapest, Hungary"]},{"name":"St. Josef Hospital, Ruhr University","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-6147","authenticated-orcid":false,"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"Heidelberg University","place":["Mannheim, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-1045","authenticated-orcid":false,"given":"Ibrahim","family":"El\u2010Battrawy","sequence":"additional","affiliation":[{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"Ruhr\u2010University Bochum","place":["Bochum, Germany"]},{"name":"St. Josef Hospital, Ruhr University","place":["Bochum, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2018.04.003"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179293"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-020-0738-6"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.028993"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2022.09"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2019.05.006"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2024.0130"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.08.018"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.541"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.1320"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2023.04.002"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-023-00937-4"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad091"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-1-18"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.12.073"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2019.100439"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.08.020"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419795112"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1154-2"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab687"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505719"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12020204"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2017.1344799"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402388101"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2015.09.008"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suab104"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2020.04.011"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243956"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313406"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008155"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2022.11.2769"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.2781"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27503-9"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells7060048"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039711"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.04.017"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00766.x"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.2782"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.2776"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2023-0880"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.133.suppl_1.P3135"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.075382"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040903"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319094"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.151893"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.20517\/jca.2023.42"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006901"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad655.3135"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.11.3228"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-051421-111814"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq7839"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959916"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1942"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316819"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01566"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.369"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001455"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2017"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139344319"},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9040168"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102259"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100194"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05201-y"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.066"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.026823"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062825"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12581"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004725"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.011387"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00178"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2797-4"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307778"},{"key":"e_1_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22225-w"},{"key":"e_1_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.3791\/61962"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.05.004"},{"key":"e_1_3_1_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37428"},{"key":"e_1_3_1_78_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0027"},{"key":"e_1_3_1_79_2","doi-asserted-by":"publisher","unstructured":"Qin J van Mil A Sluijter JPG. Biophysical stretch induced differentiation and maturation of induced pluripotent stem cell\u2010derived cardiomyocytes. 2023;141\u2013179. doi: 10.1007\/978-3-031-23965-6_7","DOI":"10.1007\/978-3-031-23965-6_7"},{"key":"e_1_3_1_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1155052"},{"key":"e_1_3_1_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114840"},{"key":"e_1_3_1_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.967659"},{"key":"e_1_3_1_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000972"},{"key":"e_1_3_1_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2021.06.009"},{"key":"e_1_3_1_85_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2021.0088"},{"key":"e_1_3_1_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2017.07.001"},{"key":"e_1_3_1_87_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176388"},{"key":"e_1_3_1_88_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124354"},{"key":"e_1_3_1_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.10.013"},{"key":"e_1_3_1_90_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP284739"},{"key":"e_1_3_1_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.025"},{"key":"e_1_3_1_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae009"},{"key":"e_1_3_1_93_2","doi-asserted-by":"publisher","DOI":"10.4103\/apc.apc_96_23"},{"key":"e_1_3_1_94_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12040536"},{"key":"e_1_3_1_95_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13061781"},{"key":"e_1_3_1_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2024.03.013"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.038308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:31:55Z","timestamp":1741861915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.038308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":95,"alternative-id":["10.1161\/JAHA.124.038308"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.038308","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e038308"}}