{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:10:01Z","timestamp":1788876601022,"version":"build-2803163510"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Arrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and sudden cardiac death, along with progressive cardiac remodeling and myocardial inflammation. This study aims to elucidate the patterns of [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010fluorodeoxyglucose ([\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG) uptake in a mouse model of plakoglobin\u2010associated cardiac disease to better understand its diagnostic potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Plakoglobin (\n                      <jats:italic toggle=\"no\">Jup<\/jats:italic>\n                      ) knockout mice developed a cardiomyopathy that presented an ACM\u2010like phenotype at 6\u2009weeks of age. Flow cytometry experiments showed a significant increase of immune cells, for example, an expansion of proinflammatory and tissue\u2010injury macrophages. In\u00a0vivo positron emission tomography and ex\u00a0vivo autoradiography showed increased [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG uptake in genotype positive hearts. A correlative analysis between [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG positivity and macrophage infiltration using CD68 and CD206 staining did not show colocalization. CD68 and CD206 positivity was primarily observed within the fibrotic scar, whereas [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG uptake was predominantly identified in CD68 and CD206\u2010negative tissue areas. Instead, [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG signal seemed to originate from cardiomyocytes adjacent to areas of fibrotic remodeling. Morphometric analysis revealed hypertrophy of these cardiomyocytes, which may reflect metabolic remodeling as a compensatory response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In our murine model of\n                      <jats:italic toggle=\"no\">Jup<\/jats:italic>\n                      \u2010related ACM, strong cardiac [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG uptake was detected, which colocalized with regional hypertrophic cardiomyocytes rather than inflammatory cells. These findings indicate that [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010FDG positron emission tomography is a valuable tool for identifying and localizing hypermetabolic areas associated with cardiac remodeling in ACM, providing insights into disease mechanisms and potential diagnostic strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038331","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:20:07Z","timestamp":1740986407000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Illuminating Cardiac Remodeling: Insights From [\n                    <sup>18<\/sup>\n                    F]\u2010Fluorodeoxyglucose Positron Emission Tomography Imaging in Plakoglobin\u2010Associated Arrhythmogenic 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