{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:12:40Z","timestamp":1788379960593,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Contemporary research in peripheral artery disease (PAD) remains limited due to lack of a national registry and low accuracy of diagnosis codes to identify patients with PAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Leveraging a novel natural language processing system that identifies PAD with high accuracy using ankle\u2010brachial index and toe\u2010brachial index values, we created a registry of 103\u2009748 patients with new\u2010onset PAD in the Veterans Health Administration. Study end points include mortality, cardiovascular events (hospitalization for acute myocardial infarction or stroke) and limb events (hospitalization for critical limb ischemia or major amputation) and were identified using Veterans Affairs and non\u2013Veterans Affairs encounters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The mean age was 70.6\u2009years; 97.3% were male, and 18.5% self\u2010identified as Black. The mean ankle\u2010brachial index value was 0.78 (SD: 0.26) and the mean toe\u2010brachial index value was 0.51 (SD: 0.19). A majority of patients were current (27.1%) or former (30.0%) smokers. Prevalence of hypertension (86.6%), heart failure (22.7%), diabetes (54.8%), chronic kidney disease (23.6%), and chronic obstructive pulmonary disease (35.4%) was high. At 1 year, 9.4% of patients had died. The 1\u2010year incidence of cardiovascular events was 5.6 per 100 patient\u2010years and limb events was 7.0 per 100 patient\u2010years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">We have successfully launched a registry of &gt;100\u2009000 patients with a new diagnosis of PAD in the Veterans Health Administration, the largest integrated health system in the United States. The incidence of death and clinical events in our cohort is high. Ongoing studies will yield important insights regarding improving care and outcomes in this high\u2010risk group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038403","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T23:43:26Z","timestamp":1742600606000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long\u2010Term Survival Study (PEARLS)"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-4513","authenticated-orcid":false,"given":"Saket","family":"Girotra","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["Dallas"]},{"name":"North Texas Veterans Affairs Medical 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