{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:48Z","timestamp":1788876588278,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sex differences in patients with hypertrophic cardiomyopathy have been elaborated by many studies. However, large studies of the association of patient sex with outcomes after surgical myectomy are scarce. This study evaluated sex disparities in a large Chinese cohort undergoing hypertrophic cardiomyopathy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The cohort encompassed 1613 patients, including 627 (38.9%) women who underwent septal myectomy between 2009 and 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      At the time of surgery, women were 6\u2009years older and had 1 year longer disease onset\u2010to\u2010surgery delay than men. They were more frequently in New York Heart Association class III\/IV and had more severe left ventricular outflow tract obstruction. Compared with men, women had a notably higher left ventricular wall thickness index and a lower extent of late gadolinium enhancement. Women also had more mutations in\n                      <jats:italic toggle=\"no\">MYH7<\/jats:italic>\n                      and fewer in\n                      <jats:italic toggle=\"no\">MYBPC3<\/jats:italic>\n                      . Postoperatively, women had a higher operative mortality rate (1.3% versus 0.1%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006). The follow\u2010up results showed no significant difference between the sexes in all\u2010cause death (hazard ratio [HR], 0.67 [95% CI, 0.38\u20131.18];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.166). A U\u2010shaped association was observed between age and death in the overall population. However, women exhibited this association more obviously at age \u226555\u2009years and men at &lt;35\u2009years. Moreover, women also had a higher risk of cardiovascular rehospitalization after surgery (HR, 1.40 [95% CI, 1.03\u20131.89];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with obstructive hypertrophic cardiomyopathy, women had a similar fatal outcome but a worse nonfatal outcome than men after surgery. Measures improving quality of life may further enhance the event\u2010free survival of female patients. Close monitoring and follow\u2010up are warranted, especially in younger men and older women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038421","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T06:16:56Z","timestamp":1740464216000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Understanding Sex Differences in Hypertrophic Cardiomyopathy Surgery: Insights From a Decade\u2010Long Cohort Study From China"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1820-1846","authenticated-orcid":false,"given":"Tao","family":"Lu","sequence":"first","affiliation":[{"name":"National Center of Cardiovascular Diseases","place":["Beijing, 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