{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:33:05Z","timestamp":1770755585260,"version":"3.50.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Electrophysiological characterization of ventricular tachycardia (VT) isthmus sites is complex and time\u2010consuming. We aimed at developing and validating a global mapping strategy during programmed ventricular stimulation (PVS) to reveal the underlying electrophysiological properties of the infarct\u2010related substrate and to enable identification of highly heterogeneous activation sites associated with protected VT isthmus sites.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Experimental study that included 22 pigs with established myocardial infarction undergoing in\u00a0vivo characterization of the anatomical and functional myocardial substrate associated with potential arrhythmogenicity. High\u2010density sequential activation maps during ventricular pacing and VT were compared with single\u2010beat maps using a 64\u2010pole basket catheter positioned in the left ventricle. Further analyses were performed using a novel local activation time\u2010dispersion score to identify regional activation time heterogeneities on both baseline drive pacing and each of the extrastimuli of the PVS protocol. Basket catheter splines covered a median of 81.2% of the endocardial surface of the left ventricle. Basket\u2010catheter\u2010derived single\u2010beat activation maps (N=16) during pacing showed a linear relationship with high\u2010density sequential activation maps. Induction of ventricular arrhythmias was associated with higher local activation time\u2010dispersion score values on single\u2010beat global maps during PVS (N=6, 46 arrhythmia induction attempts). Single\u2010beat\u2010derived local activation time\u2010dispersion score maps during successive coupled extrastimuli of the PVS showed a progressive increase in the predictive performance to identify monomorphic VT isthmus sites within the scar region (area under the curve\u2009=\u20090.779 in S2, area under the curve\u2009=\u20090.859 in S4; N=7).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Sixty\u2010four\u2010pole\u2010derived single\u2010beat local activation time\u2010dispersion score global maps during PVS identify infarct\u2010related endocardial regions with highly heterogeneous activation times that are associated with protected VT isthmus sites.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038441","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:36:13Z","timestamp":1732275373000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Dispersion of Activation in Single\u2010Beat Global Maps During Programmed Ventricular Stimulation Identifies Infarct\u2010Related Ventricular Tachycardia Isthmus Sites"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-0711","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Redondo\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) Novel Arrhythmogenic Mechanisms Program Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-3325","authenticated-orcid":false,"given":"Alba","family":"Ramos\u2010Prada","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) Novel Arrhythmogenic Mechanisms Program Madrid Spain"},{"name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-3507","authenticated-orcid":false,"given":"Jorge G.","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) Novel Arrhythmogenic Mechanisms Program Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Cardiovascular Institute Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-4011","authenticated-orcid":false,"given":"David","family":"Calvo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC) Cardiovascular Institute Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1427-3870","authenticated-orcid":false,"given":"Javier","family":"S\u00e1nchez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Philips healthcare Iberia Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-8746","authenticated-orcid":false,"given":"Daniel","family":"Enr\u00edquez\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain"},{"name":"Complexo Hospitalario Universitario A Coru\u00f1a. Servicio de Cardiolog\u00eda, Instituto de Investigaci\u00f3n Biom\u00e9dica A Coru\u00f1a (INIBIC) A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-1868","authenticated-orcid":false,"given":"Manuel","family":"Marina\u2010Breysse","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) Novel Arrhythmogenic Mechanisms Program Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-9135","authenticated-orcid":false,"given":"Jose Manuel","family":"Alfonso\u2010Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC) Novel Arrhythmogenic Mechanisms Program Madrid 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