{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:49Z","timestamp":1788876589428,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Plaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Small dense low\u2010density lipoprotein cholesterol (sdLDL\u2010C) is considered as the most atherogenic lipoprotein. This study aims to investigate the relationship between sdLDL\u2010C level and PP in patients with stable coronary artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a retrospective analysis of 146 lesions in 86 patients by repeat intravascular ultrasound examinations from January 2020 to May 2023. PP was determined by increases in percent atheroma volume, defined as the atheroma volume in proportion to the volume occupied by the entire vascular wall, \u22655% during follow\u2010up. Time\u2010averaged values were calculated for all cardiometabolic parameters including sdLDL\u2010C. Multivariate logistic regression analysis was performed to interrogate the association between time\u2010averaged sdLDL\u2010C and PP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      During a median follow\u2010up of 12.6\u2009months, PP was found in 65 lesions (44.5%), and mean changes in percent atheroma volume were 4.1%\u00b110.2%. A positive correlation was observed between time\u2010averaged sdLDL\u2010C and changes in total atheroma volume (Pearson\n                      <jats:italic toggle=\"no\">r<\/jats:italic>\n                      =0.29,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006), especially in diabetic patients (Pearson\n                      <jats:italic toggle=\"no\">r<\/jats:italic>\n                      =0.58,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). After multivariate adjustment, every 0.1\u2010mmol\/L increase in time\u2010averaged sdLDL\u2010C conferred a 1.2\u2010fold increased risk of PP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our findings suggest that sdLDL\u2010C is an independent risk factor of PP in patients with coronary artery disease. Intensive control of sdLDL\u2010C along with other risk factors should be considered to mitigate PP and improve cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038580","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:09:02Z","timestamp":1740550142000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Suboptimal Control of Small Dense Low\u2010Density Lipoprotein Cholesterol Is Associated With Coronary Plaque Progression: An Intravascular Ultrasound Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Abulikemu","family":"Amuti","sequence":"first","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5935-9133","authenticated-orcid":false,"given":"You Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3618-9032","authenticated-orcid":false,"given":"He","family":"Yuan","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-8057","authenticated-orcid":false,"given":"Shuo","family":"Feng","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan Poh","family":"Tay","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6428-1402","authenticated-orcid":false,"given":"Si Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9206-1105","authenticated-orcid":false,"given":"Xin Rui","family":"Wu","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7093-6449","authenticated-orcid":false,"given":"Le Yuan","family":"Tao","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-8008","authenticated-orcid":false,"given":"Lin","family":"Lu","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-4274","authenticated-orcid":false,"given":"Chen Die","family":"Yang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-8041","authenticated-orcid":false,"given":"Xiao Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Ruijin Hospital, Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai Jiao\u2010Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.012"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03392-8"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.050"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09880-x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0924-z"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.189"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.123.016481"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042000"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.030071"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz455"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.019140"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.63229"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.01.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0904-3"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-9136(199807)15:7<539::Aid-dia668>3.0.Co;2-s"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23660"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.041149"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab551"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.013876"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01175-5"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.11.019"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq280"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac309"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.05.012"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.03.016"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.026"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2020.12.007"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-07726-y"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht084"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.02.001"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.04.009"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-008-0059-2"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01015-6"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5597028"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.123.045601"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.49841"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-015-0034-1"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.17.6.1011"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.Cir.0000131511.50734.44"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410130125037"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.059"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.038580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:36:58Z","timestamp":1788874618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.038580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,4]]}},"alternative-id":["10.1161\/JAHA.124.038580"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.038580","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e038580"}}