{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:09:56Z","timestamp":1788876596361,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Cardiorenal syndrome type 1 is characterized by the development of acute kidney injury following acute cardiac illness and notably acute myocardial infarction (MI). Acute kidney injury is considered an independent risk factor that increases mortality rate substantially. Nicotinamide adenine dinucleotide (NAD) is an important coenzyme in energy metabolism and oxidative phosphorylation, and in its oxidized form it is a substrate for multiple NAD\n                      <jats:sup>+<\/jats:sup>\n                      \u2010dependent enzymes such as sirtuins and poly\u2010ADP ribose polymerases. Decreased cardiac NAD levels, along with a downregulation of NAMPT (nicotinamide phosphoribosyl transferase), have been reported following MI. A compensatory upregulation in NMRK (nicotinamide riboside kinase) 2, an NAD\n                      <jats:sup>+<\/jats:sup>\n                      biosynthetic enzyme that uses nicotinamide riboside (NR) to generate NAD\n                      <jats:sup>+<\/jats:sup>\n                      , takes place in the heart after MI, but the impact on kidney NAD metabolism and function has not been addressed before.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">MI was induced by ligating the left anterior descending coronary artery in 2\u2010month\u2010old C57BL6\/J mice, followed by the administration of NR (IP injection, 400\u2009mg\/kg per day) for 4 and 7\u2009days. We hypothesized that NR treatment could be a potentially promising therapy for MI\u2010induced acute kidney injury. Our findings showed no significant improvement in cardiac ejection fraction following NR treatment at days 4 and 7 post\u2010MI, whereas kidney functions were enhanced and morphological alterations and cell death decreased. The observed renal protection seems to be mediated by an upregulation of NAMPT\u2010mediated increase in renal NAD levels, notably in the distal tubules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our findings indicate that NR could potentially be a promising therapy for acute kidney injury following an early stage of MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.038603","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:05:57Z","timestamp":1740549957000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction\u2010Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransferase\u2010Mediated Nicotinamide Dinucleotide Levels"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2636-0242","authenticated-orcid":false,"given":"Nada J.","family":"Habeichi","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay, INSERM, Signaling and Cardiovascular Pathophysiology UMR\u2010S 1180","place":["Orsay, France"]},{"name":"American University of Beirut, Faculty of Medicine","place":["Beirut, Lebanon"]},{"name":"American University of Beirut Medical Center","place":["Beirut, Lebanon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-7254","authenticated-orcid":false,"given":"Ghadir","family":"Amin","sequence":"additional","affiliation":[{"name":"American University of Beirut, Faculty of Medicine","place":["Beirut, Lebanon"]},{"name":"American University of Beirut Medical Center","place":["Beirut, Lebanon"]},{"name":"School of Medicine, University of Mississippi Medical 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