{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:40:39Z","timestamp":1793047239814,"version":"4.5.0"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"jah311057-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Studying trends in mortality is essential to advance understanding of population health. Further evaluation of long\u2010term heart disease mortality trends and subtypes in the United States is needed to guide public health and clinical interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311057-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This study used the National Vital Statistics System Centers for Disease Control and Prevention Wide\u2010Ranging Online Data for Epidemiologic Research data for adults aged 25 years and older in the United States from 1970 to 2022. Outcomes included absolute number and age\u2010adjusted mortality of total heart disease, ischemic heart disease, and other heart disease subtypes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311057-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">From 1970 to 2022, overall age\u2010adjusted heart disease mortality decreased by 66% from 1970 to 2022 (from 761 to 258 per 100\u2009000). In 1970, 91% of all heart disease deaths were ischemic, declining to 53% of all heart disease deaths in 2022. From 1970 to 2022, age\u2010adjusted mortality decreased by 89% for acute myocardial infarction (from 354 to 40 per 100\u2009000) and 81% for all ischemic heart disease (from 693 to 135 per 100\u200900). In contrast, from 1970 to 2022 age\u2010adjusted mortality for other heart disease subtypes increased by 81% (from 68 to 123 per 100\u2009000), with the greatest increases in heart failure (146% increase), hypertensive heart disease (106% increase) and arrhythmias (450% increase).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311057-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Heart disease mortality has decreased over the past 5 decades. There is an increasing burden of mortality from other heart conditions including heart failure, hypertensive heart disease, and arrhythmias. Further efforts must be undertaken to address the growing challenge of these other heart conditions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038644","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:33:54Z","timestamp":1750833234000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Heart Disease Mortality in the United States, 1970 to 2022"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-1655","authenticated-orcid":false,"given":"Sara J.","family":"King","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-8031","authenticated-orcid":false,"given":"Tenzin Yeshi","family":"Wangdak Yuthok","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-4754","authenticated-orcid":false,"given":"Adrian M.","family":"Bacong","sequence":"additional","affiliation":[{"name":"Stanford Universitsy School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Stanford Universitsy School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-2979","authenticated-orcid":false,"given":"Dhruv S.","family":"Kazi","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. 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