{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:55:30Z","timestamp":1776779730475,"version":"3.51.2"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"jah311074-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients presenting with acute coronary syndromes (ACS), impaired coronary blood flow (CBF) after percutaneous coronary interventions (PCI) is linked to mortality. We developed a novel angiography\u2010based approach for blood flow quantification using automatic contrast bolus tracking. Therefore, this study aimed to investigate the clinical impact of angiography\u2010based blood flow quantification on major adverse cardiovascular events (MACE) after PCI in patients with ACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311074-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Prospective, multicenter, nested case\u2013control study of patients presenting ACS. A propensity score was used to match patients with and without MACE at 1\u2009year of follow\u2010up. MACE was defined as cardiovascular death, myocardial infarction, hospitalization for heart failure, or ischemia\u2010driven revascularization. CBF was measured automatically from angiograms after PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311074-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              One hundred sixty\u2010two patients were included. The mean age was 68.3\u00b113.0\u2009years, 83% were male, and 33% had diabetes. Overall, 66% of patients presented with ST\u2010segment\u2013elevation myocardial infarction. CBF after PCI was lower after ST\u2010segment\u2013elevation myocardial infarction compared with other clinical presentations (74.1\u00b147.0\u2009mL\/min ST\u2010segment\u2013elevation myocardial infarction, 89.1\u00b145.8\u2009mL\/min, non\u2010ST\u2010segment\u2013elevation myocardial infarction, 95.7\u00b148.8\u2009mL\/min, unstable angina,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.046). Patients with low post\u2010PCI CBF (&lt;54.3\u2009mL\/min) had an increased risk of MACE (hazard ratio, 2.11 [95% CI, 1.35\u20133.28],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311074-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">After PCI, automatic quantification of CBF using angiography was associated with MACE in patients with ACS. Risk stratification using post\u2010PCI CBF\u2010derived angiography may enable tailored management strategies for individuals with ACS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038770","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:58:39Z","timestamp":1751003919000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Angiography\u2010Based Blood Flow Quantification After Revascularization in Acute Coronary Syndromes"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-6497","authenticated-orcid":false,"given":"Koshiro","family":"Sakai","sequence":"first","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]},{"name":"Showa University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8746","authenticated-orcid":false,"given":"Takuya","family":"Mizukami","sequence":"additional","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]},{"name":"Showa University","place":["Tokyo, Japan"]},{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2709-3186","authenticated-orcid":false,"given":"Hirofumi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Aichi Medical University","place":["Nagakute, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-0273","authenticated-orcid":false,"given":"Frederic","family":"Bouisset","sequence":"additional","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]},{"name":"Toulouse University Hospital","place":["Toulouse, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Botti","sequence":"additional","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]},{"name":"IRCCS Ospedale San Raffaele","place":["Milan, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-4779","authenticated-orcid":false,"given":"Nobuaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Nippon Medical School Chiba Hokusoh Hospital","place":["Chiba, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Takano","sequence":"additional","affiliation":[{"name":"Nippon Medical School Chiba Hokusoh Hospital","place":["Chiba, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seita","family":"Kondo","sequence":"additional","affiliation":[{"name":"Showa University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-6117","authenticated-orcid":false,"given":"Tomoyo","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Tsuchiura Kyodo General Hospital","place":["Ibaraki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-5292","authenticated-orcid":false,"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Tsuchiura Kyodo General Hospital","place":["Ibaraki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4264-0439","authenticated-orcid":false,"given":"Kohei","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Showa University Koto Toyosu Hospital","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-0937","authenticated-orcid":false,"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"Juntendo University Shizuoka Hospital","place":["Shizuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-468X","authenticated-orcid":false,"given":"Tomotaka","family":"Dohi","sequence":"additional","affiliation":[{"name":"Juntendo University Graduate School of Medicine","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-3485","authenticated-orcid":false,"given":"Hiroyoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Showa University Fujigaoka Hospital","place":["Yokohama, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Yokohama Minami Kyosai Hospital","place":["Yokohama, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-4352","authenticated-orcid":false,"given":"Satoru","family":"Mitomo","sequence":"additional","affiliation":[{"name":"New Tokyo Hospital","place":["Chiba, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-0090","authenticated-orcid":false,"given":"Sunao","family":"Nakamura","sequence":"additional","affiliation":[{"name":"New Tokyo Hospital","place":["Chiba, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-0262","authenticated-orcid":false,"given":"Takumi","family":"Higuma","sequence":"additional","affiliation":[{"name":"Kawasaki Municipal Tama 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Belgium"]},{"name":"Sapienza University","place":["Rome, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-8244","authenticated-orcid":false,"given":"Jeroen","family":"Sonck","sequence":"additional","affiliation":[{"name":"OLV Clinic","place":["Aalst, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-7538","authenticated-orcid":false,"given":"Toshiro","family":"Shinke","sequence":"additional","affiliation":[{"name":"Showa University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Bouwman","sequence":"additional","affiliation":[{"name":"Pie Medical Imaging","place":["Maastricht, The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Aben","sequence":"additional","affiliation":[{"name":"Pie Medical Imaging","place":["Maastricht, The 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