{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:54:48Z","timestamp":1779368088202,"version":"3.53.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Inflammatory arthritis is recognized to increase cardiovascular disease risk, but its association with degenerative aortic stenosis is not well understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This prospective cohort study used participants from the UK Biobank, focusing on 4 major types of inflammatory arthritis, including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and gout. The primary outcome was the incidence of degenerative aortic stenosis. The primary analysis used Cox proportional hazards models to evaluate the association between inflammatory arthritis and the long\u2010term risk of degenerative aortic stenosis, as well as to explore potential effect modifiers. Genetic risk was evaluated using polygenic risk scores and self\u2010reported family history of cardiovascular diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The study included 497\u2009567 participants, with 271\u2009129 women (54.5%) and 468\u2009015 White individuals (94.1%). The median age was 58\u2009years. Over a median follow\u2010up of 12.58\u2009years, 4571 cases (0.9%) of degenerative aortic stenosis were identified. Compared with the control group, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and gout were associated with increased risks of degenerative aortic stenosis by 54% (hazard ratio [HR], 1.54 [95% CI, 1.28\u20131.85]), 72% (HR, 1.72 [95% CI, 1.19\u20132.50]), 176% (HR, 2.76 [95% CI, 1.43\u20135.32]), and 36% (HR, 1.36 [95% CI, 1.20\u20131.54]), respectively. These associations were independent of genetic risk (\n              <jats:italic>P<\/jats:italic>\n              for interaction&gt;0.05). Additionally, we identified significant interactions between sex (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.036), age (\n              <jats:italic>P<\/jats:italic>\n              for interaction&lt;0.001), and socioeconomic status (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.014) with rheumatoid arthritis, ankylosing spondylitis, and gout on the incidence of degenerative aortic stenosis, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Inflammatory arthritis is significantly associated with an increased long\u2010term risk of degenerative aortic stenosis, underscoring the need for enhanced risk assessment for degenerative aortic stenosis in these populations.<\/jats:p>\n          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