{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:28:53Z","timestamp":1791919733931,"version":"4.3.4"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Neurovascular coupling is a fundamental aspect of brain function by regulating cerebral blood flow in response to regional neuronal activity. Increasing evidence suggest neurovascular decoupling occurs early in the progression of Alzheimer disease (AD), potentially reflecting early vascular damage. Therefore, understanding the relationship between neurovascular coupling and established vascular risk factors for AD is essential to gain deeper insights into the vascular mechanisms underlying AD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This cross\u2010sectional observational study investigated the association between neurovascular coupling and vascular risk factors for AD, specifically small vessel disease magnetic resonance imaging markers, cardiovascular risk factors, and the apolipoprotein E genotype. The cohort included 119 participants diagnosed with subjective cognitive impairment, mild cognitive impairment, and AD\u2010related dementia, as well as individuals without cognitive complaints. Neurovascular coupling was measured by blood\u2010oxygen\u2010level\u2010dependent functional magnetic resonance imaging amplitude in response to visual stimulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Our findings revealed that decreased neurovascular coupling is linked to structural brain changes typically seen in small vessel disease; specifically we found an association between neurovascular coupling and white matter hyperintensities load (\n              <jats:italic>\u03b2<\/jats:italic>\n              =\u22120.199,\n              <jats:italic>P<\/jats:italic>\n              =0.030) and presence of lobar intracerebral hemorrhage (\n              <jats:italic>\u03b2<\/jats:italic>\n              =\u22120.228,\n              <jats:italic>P<\/jats:italic>\n              =0.011).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">This raises the suggestion that a decreased neurovascular coupling in the disease process of AD is related to comorbid small vessel disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038819","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T11:23:56Z","timestamp":1739532236000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-1746","authenticated-orcid":false,"given":"Suzanne E.","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8793-6201","authenticated-orcid":false,"given":"Nadieh","family":"Drenth","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-4768","authenticated-orcid":false,"given":"Anne","family":"Hafkemeijer","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"},{"name":"Institute of Psychology Leiden University Leiden The Netherlands"},{"name":"Leiden Institute for Brain and Cognition Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2864-8426","authenticated-orcid":false,"given":"Gerda","family":"Labadie","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-3967","authenticated-orcid":false,"given":"Marie\u2010No\u00eblle W.","family":"Witjes\u2010An\u00e9","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and department of Psychiatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-5428","authenticated-orcid":false,"given":"Frank","family":"Baas","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-3264","authenticated-orcid":false,"given":"Jeroen P.","family":"Vreijling","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-654X","authenticated-orcid":false,"given":"Gerard J.","family":"Blauw","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Geriatrics Haaglanden Medical Center The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-4779","authenticated-orcid":false,"given":"Serge A. 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