{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:06:20Z","timestamp":1789239980374,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Mitral valve transcatheter edge\u2010to\u2010edge repair (M\u2010TEER) has emerged as a viable therapy option in patients with severe mitral regurgitation and high surgical risk. Although atrial fibrillation is common among patients undergoing M\u2010TEER, the optimal anticoagulatory treatment after the intervention is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">A single\u2010center retrospective observational analysis was conducted using data from the M\u2010TEER registry at the University Hospital Cologne collected from 2019 untill 2021 including patients undergoing M\u2010TEER between November 2012 and April 2019. Patients with atrial fibrillation receiving consistent anticoagulation following M\u2010TEER were categorized into a direct oral anticoagulant or a vitamin K antagonist (VKA) group. The primary end point was a composite of ischemic cerebrovascular and bleeding events. Additionally, overall survival was assessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 613 patients undergoing M\u2010TEER, 206 met the inclusion criteria, with 61 receiving direct oral anticoagulants and 145 receiving VKAs. After a median follow\u2010up of 833 (interquartile range, 355\u20131271) days, the incidence of the composite primary end point did not differ between direct oral anticoagulant and VKA groups (hazard ratio [HR], 0.51 [95% CI, 0.23\u20131.12];\n              <jats:italic>P<\/jats:italic>\n              =0.07). Similarly, rates of ischemic cerebrovascular events and bleeding events were similar between groups. However, the overall mortality rate was higher in the VKA group (HR, 2.56 [95% CI, 1.54\u20134.26];\n              <jats:italic>P<\/jats:italic>\n              =0.002). In the multivariable analysis, oral anticoagulation with a VKA was an independent predictor for death (adjusted HR, 2.23 [95% CI, 1.08\u20135.06];\n              <jats:italic>P<\/jats:italic>\n              =0.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Our findings suggest that direct oral anticoagulants may offer comparable efficacy and safety to VKAs in preventing thromboembolic events following M\u2010TEER in patients with atrial fibrillation. Further randomized trials are needed to confirm these results and establish optimal anticoagulation strategies in this patient population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038834","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:16:06Z","timestamp":1738577766000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge\u2010to\u2010Edge Repair in Patients With Atrial Fibrillation: A Single\u2010Center Observational Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-3295","authenticated-orcid":false,"given":"Jan\u2010Hendrik","family":"Schipper","sequence":"first","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine University of Cologne Germany"},{"name":"Heart 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