{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:39:35Z","timestamp":1794015575617,"version":"4.8.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Studies in young patients with stroke identified coronary artery disease (CAD) as a main contributor to mortality. In the present NOR\u2010SYS (Norwegian Stroke in the Young Study), we aimed to investigate the prevalence of CAD, and the impact on new vascular events and mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 385 patients with ischemic stroke, aged \u226460\u2009years, were included. CAD was defined as a history of CAD or positive coronary imaging (computed tomography or coronary angiography).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Mean age was 49.6\u2009years, and 68.1% were men. The prevalence of CAD was 25.2% (n=97) (nonobstructive, 9.6% [n=37]; and obstructive, 15.6% [n=60]). In the subsample of patients without clinical CAD but with femoral plaque on ultrasound (n=58) who underwent cardiac computed tomography, 46% (n=27) had nonobstructive CAD and 28% (n=16) had obstructive CAD. During a median follow\u2010up of 10.1\u2009years, 36 patients (9.4%) died, 84 (21.8%) reached a composite end point of new stroke, myocardial infarction, or death, whereas 64 (16.6%) had a composite end point of new stroke or death. Event\u2010free survival was significantly lower in patients with obstructive CAD versus no CAD or nonobstructive CAD (log\u2010rank\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In the multivariable Cox regression models, CAD was a strong and independent predictor of all\u2010cause mortality (hazard ratio [HR], 2.20 [95% CI, 1.05\u20134.60];\n              <jats:italic>P<\/jats:italic>\n              =0.037) and the composite end point of death or recurrent ischemic stroke (HR, 3.24 [95% CI, 1.46\u20137.20];\n              <jats:italic>P<\/jats:italic>\n              =0.004).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In young and middle\u2010aged ischemic stroke survivors, a quarter of patients had CAD. CAD was an independent predictor of recurrent stroke and mortality. In patients without previous CAD, but femoral plaque on ultrasound, nearly a half had nonobstructive and one\u2010fourth had obstructive CAD. Systematic screening with cardiac computed tomography may identify high\u2010risk patients after ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01597453.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.038899","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:34:31Z","timestamp":1741862071000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Burden of Coronary Artery Disease as a Predictor of New Vascular Events and Mortality in Patients With Ischemic Stroke: Insights From the Norwegian Stroke in the Young Study"],"prefix":"10.1161","author":[{"given":"Khuluud Abdi","family":"Jibril","sequence":"first","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kier Jan","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beenish","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-3131","authenticated-orcid":false,"given":"Halvor","family":"Naess","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Fromm","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halvor","family":"\u00d8ygarden","sequence":"additional","affiliation":[{"name":"Hospital of Southern Norway","place":["Kristiansand, Norway"]},{"name":"University of Oslo","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin Modalsli","family":"Sand","sequence":"additional","affiliation":[{"name":"S\u00f8rlandet Hospital","place":["Flekkefjord, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Meijer","sequence":"additional","affiliation":[{"name":"Utrecht University","place":["Utrecht, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abukar","family":"Mohamed Ali","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-8707","authenticated-orcid":false,"given":"\u00d8yvind","family":"Bleie","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-884X","authenticated-orcid":false,"given":"Elisabeth","family":"Skaar","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-6040","authenticated-orcid":false,"given":"Ulrike","family":"Waje\u2010Andreassen","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-5019","authenticated-orcid":false,"given":"Sahrai","family":"Saeed","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]},{"name":"University of 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