{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:45:05Z","timestamp":1788608705939,"version":"build-2803163510"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Identification of individuals at risk for major adverse cardiovascular events is essential for contemporary management of patients with repaired tetralogy of Fallot. We sought to identify clinical and cardiovascular magnetic resonance imaging (CMR) predictors of adverse clinical outcomes in repaired tetralogy of Fallot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Children and adults prospectively enrolled in the CORRELATE (Comprehensive Outcomes Registry Late After Tetralogy of Fallot Repair) registry followed in North American, European, and Asian centers were studied. All patients had at least moderate pulmonary regurgitation and CMR at enrollment. Time\u2010to\u2010event analyses were performed from CMR completion to primary outcome, defined as mortality, resuscitated sudden death, sustained ventricular arrhythmia, or heart failure admission. Principal component analysis was used to create distinct CMR scores that collectively captured 80% of the variance among 10 CMR measures (systolic function, biventricular volumes\/mass, and biatrial areas).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">In 720 patients (55% male, median age 30.3\u00b114\u2009years, 78% adult) with mean follow\u2010up 5.7\u00b11.8\u2009years, the primary outcome occurred in 38 patients (5.2%) at a rate of 0.9\/100 patient\u2010years. A well\u2010calibrated risk scoring system was created for prediction of the primary outcome at 5 years based on 5 predictors: age, diabetes, right ventricular systolic pressure, and 2 CMR principal component scores (predominantly reflecting atrial areas in the first principal component score and ventricular volumes in the second principal component score) (c\u2010statistic for the composite risk score 0.79 [95% Cl, 0.71\u20130.88]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Clinical and imaging characteristics can contribute to risk prediction in repaired tetralogy of Fallot. Further study will be required to evaluate the utility of a risk scoring system for identification of individuals who may benefit from enhanced surveillance, intensified medical therapy, and\/or optimally timed intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.039006","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:56:56Z","timestamp":1744264616000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Outcome Prediction After Tetralogy of Fallot Repair: A Prospective Clinical and Cardiovascular Magnetic Resonance Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-6438","authenticated-orcid":false,"given":"Rachel M.","family":"Wald","sequence":"first","affiliation":[{"name":"Peter Munk Cardiac Centre, University Health Network, University of Toronto","place":["Toronto, Canada"]},{"name":"University Health Network, University of Toronto","place":["Toronto, Canada"]},{"name":"Hospital for Sick Children, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-6399","authenticated-orcid":false,"given":"George","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University Health Network\/Sinai Health System, and Institute of Health Policy, Management and Evaluation, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Caldarone","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Texas Children\u2019s Hospital","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-3169","authenticated-orcid":false,"given":"Nagib","family":"Dahdah","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0489-2523","authenticated-orcid":false,"given":"Frederic","family":"Dallaire","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke and University of Sherbrooke","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-0290","authenticated-orcid":false,"given":"Christian","family":"Drolet","sequence":"additional","affiliation":[{"name":"Laval University Hospital, Faculty of Medicine, Laval University","place":["Qu\u00e9bec City, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-0246","authenticated-orcid":false,"given":"Michael E.","family":"Farkouh","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Centre, University Health Network, University of Toronto","place":["Toronto, Canada"]},{"name":"Cedars\u2010 Sinai Health System","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Grewal","sequence":"additional","affiliation":[{"name":"St Paul\u2019s Hospital, University of British Columbia","place":["Vancouver, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-8611","authenticated-orcid":false,"given":"Camille","family":"Hancock\u2010Friesen","sequence":"additional","affiliation":[{"name":"Childrens\u2019 Nebraska, University of Nebraska Medical Center","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0947-604X","authenticated-orcid":false,"given":"Edward J.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Centre, University Health Network, University of Toronto","place":["Toronto, Canada"]},{"name":"Baylor College of Medicine, Texas Children\u2019s Hospital","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri Rani","family":"Karur","sequence":"additional","affiliation":[{"name":"University Health Network, University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Keir","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne H.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Peter Munk Cardiac Centre, University Health Network, University of Toronto","place":["Toronto, Canada"]},{"name":"Equilibria Psychological 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