{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:18:46Z","timestamp":1786220326059,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,20]]},"abstract":"<jats:sec id=\"jah310877-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High\u2010degree atrioventricular block with the need for permanent pacemaker (PPM) implantation represents a frequent complication after transcatheter aortic valve implantation (TAVI). Extension of indication for TAVI toward subjects with lower surgical risk requires reduction of the likelihood for the need for PPM implantation. The aim of the current analysis was to identify predictors of the need for PPM implantation after TAVI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310877-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In a cohort of 1500 consecutive patients without a PPM undergoing transfemoral TAVI, clinical and procedural characteristics as well as parameters derived from cardiac computed tomography, such as membranous septal length and calcium volumes of the aortic valve cusps and the left ventricular outflow tract were assessed. Median calcium volume of the aortic valve was 552 mm\n              <jats:sup>3<\/jats:sup>\n              (interquartile range [IQR]: 340\u2013811 mm\n              <jats:sup>3<\/jats:sup>\n              ) in the group of subjects requiring a PPM, which was higher than in the group of subjects not requiring PPM implantation (455 mm\n              <jats:sup>3<\/jats:sup>\n              [IQR: 245\u2013723 mm\n              <jats:sup>3<\/jats:sup>\n              ],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              <jats:sub>adj<\/jats:sub>\n              =0.001). The same was true for calcification of the noncoronary cusp (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              <jats:sub>adj<\/jats:sub>\n              =0.027), left coronary cusp (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              <jats:sub>adj<\/jats:sub>\n              =0.033), and right coronary cusp (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              <jats:sub>adj<\/jats:sub>\n              =0.006). In multivariable analysis, calcium volume of the noncoronary cusp (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.039; odds ratio [OR], 1.089 per 100\u2009mm\n              <jats:sup>3<\/jats:sup>\n              ), preexisting complete right bundle\u2010branch block (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001; OR, 9.402), and implantation of a self\u2010expandable prosthesis (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001; OR, 1.856) were significantly associated with PPM implantation after TAVI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310877-sec-0003\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The current analysis offers a detailed examination of predictors for the need for PPM implantation after TAVI. Our results may contribute to improved risk stratification on the need for PPM implantation after TAVI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039020","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:37:37Z","timestamp":1747301857000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Anatomical and Functional Predictors of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-6304","authenticated-orcid":false,"given":"Susanne","family":"Jung","sequence":"first","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg, University Hospital Erlangen","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kondruweit","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg, University Hospital Erlangen","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-4101","authenticated-orcid":false,"given":"Mohamed","family":"Marwan","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg, University Hospital Erlangen","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-095X","authenticated-orcid":false,"given":"Stephan","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg, University Hospital Erlangen","place":["Erlangen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2022.05.006"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12181-020-00398-w"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy699"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.003"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.033"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx785"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy097"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01509-8"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.045"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025103"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx688"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.06.103"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz924"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq094"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev343"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.056"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24915"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.11.020"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.08.034"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2018-000972"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab232"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2233-0"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.06.015"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.05.010"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-017-1158-2"},{"key":"e_1_3_1_29_2","first-page":"173","article-title":"The incidence of transcatheter aortic valve implantation\u2010related heart block in self\u2010expandable Medtronic CoreValve and balloon\u2010expandable Edwards valves","volume":"24","author":"Liang M","year":"2012","unstructured":"Liang M, Devlin G, Pasupati S. 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