{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:06:03Z","timestamp":1788303963829,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Acute myocardial ischemia (AMI)\u2010triggered ventricular arrhythmias are closely linked to maladaptive sympathetic hyperactivity mediated via the left stellate ganglion (LSG). Although M\u2010type potassium channels regulate neuronal excitability and hold therapeutic potential for neurological disorders, their role in intrinsic LSG neurons during ischemia remains unexplored. We investigated whether pharmacological M\u2010channel activation in the LSG mitigates sympathetic overdrive and arrhythmogenesis in AMI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Twenty\u2010four beagles underwent LSG microinjection of either vehicle (n=12) or retigabine (M\u2010channel activator, 50 \u03bcM; n=12) 30 minutes before AMI induction. We assessed (1) neural parameters (LSG electrophysiology, plasma norepinephrine levels, and c\u2010fos+\/tyrosine hydroxylase+ neuron expression); (2) cardiac electrophysiological parameters (beat\u2010to\u2010beat repolarization variability, spatial dispersion of effective refractory period and action potential duration, ventricular fibrillation threshold, and spontaneous ventricular arrhythmias incidence); and (3) autonomic and hemodynamic measures (heart rate variability and blood pressure). Retigabine pretreatment significantly suppressed ischemia\u2010induced LSG hyperactivity and reduced sympathetic activation markers compared with controls. Treated animals exhibited attenuated repolarization variability and reduced electrophysiological heterogeneity in ischemic myocardium. The retigabine group demonstrated a higher ventricular fibrillation threshold (26.67\u00b12.61 versus 12.33\u00b11.76 voltage (V),\n              <jats:italic>P<\/jats:italic>\n              =0.0008) and a lower incidence of ventricular arrhythmias during AMI, with only negligible effects on baseline cardiac repolarization duration or LSG function before ischemia induction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Targeted activation of LSG M\u2010channels with retigabine stabilizes ischemia\u2010induced sympathetic hyperactivity, promotes cardiac autonomic balance, preserves repolarization homogeneity, and ultimately mitigates arrhythmic susceptibility. These findings highlight ganglionic M\u2010channel modulation as a translatable strategy to suppress neurogenic arrhythmogenesis in AMI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039059","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T10:28:21Z","timestamp":1742207301000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted M\u2010Channel Activation in the Left Stellate Ganglion Protects Against Ischemia\u2010Induced Ventricular Arrhythmias in Canines"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1578-0913","authenticated-orcid":false,"given":"Jin\u2010qiang","family":"Peng","sequence":"first","affiliation":[{"name":"Renmin Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Cardiovascular Research Institute of Wuhan University","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Cardiology","place":["Wuhan, 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