{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:23:14Z","timestamp":1791904994139,"version":"4.3.4"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"<jats:sec id=\"jah310861-sec-1001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">High systolic blood pressure (HSBP) is a significant public health issue, increasing the risk of various chronic and acute diseases. This study comprehensively analyzes the HSBP\u2010attributed burden in the Eastern Mediterranean Region (EMR).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310861-sec-1002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We extracted and analyzed data on deaths, disability\u2010adjusted life\u2010years (DALYs), years of life lost, years lived with disability, and summary exposure values (SEVs) related to HSBP from the Global Burden of Disease (GBD) 2021 study for the EMR countries from 1990 to 2021.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310861-sec-1003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In 2021, HSBP accounted for an estimated age\u2010standardized death rate of 228.4 (95% UI: 189.6 to 266) and DALYs rate of 4554.9 (3719.7 to 5279.6) per 100,000 population in the EMR. From 1990 to 2021, there was a 12.7% and 14.1% decline in age\u2010standardized death and DALYs rates linked to HSBP, respectively, with greater reduction among women. During this period, all countries except Pakistan and Libya experienced a decrease in age\u2010standardized death and DALYs rates, and also countries with higher socio\u2010demographic index (SDI) reported a lower burden attributable to HSBP in 2021. Despite the overall reduction in burden, age\u2010standardized SEVs of HSBP increased by 21.3% (12.2% to 31.7%) from 1990 to 2021, with a more significant rise in men than in women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah310861-sec-1004\" xml:lang=\"en\">\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p xml:lang=\"en\">While the HSBP\u2010attributed burden has decreased in the EMR from 1990 to 2021, the increasing trend in age\u2010standardized SEVs indicates a rising exposure. Therefore, implementing effective strategies aimed at further reducing the burden and exposure values of HSBP in this region is essential.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039158","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T11:11:27Z","timestamp":1748517087000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Burden of High Systolic Blood Pressure in the Eastern Mediterranean Region, 1990 to 2021: Results From the Global Burden of Disease Study 2021"],"prefix":"10.1161","volume":"14","author":[{"given":"Malihe","family":"Rezaee","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Shahid Beheshti University of Medical Sciences","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u2010Mahdi","family":"Bastan","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Yaghoobi","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Shahid Beheshti University of Medical Sciences","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4227","authenticated-orcid":false,"given":"Amir Hossein","family":"Behnoush","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-3099","authenticated-orcid":false,"given":"Kaveh","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences","place":["Tehran, Iran"]},{"name":"Tehran University of Medical Sciences","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.754778"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.20788"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16534"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044838"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102034"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00933-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00367-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.6069\/dwqg-3z75"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00532-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30388-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)01301-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12861"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00559-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-020-00218-z"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00476-8"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy148"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-019-09888-z"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00429-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30386-3"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-09298-w"},{"key":"e_1_3_2_25_2","first-page":"83","article-title":"An analysis of the Saudi health\u2010care system's readiness to change in the context of the Saudi National Health\u2010care Plan in Vision 2030","volume":"12","author":"Alharbi MF","year":"2018","unstructured":"Alharbi MF. 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