{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:50:18Z","timestamp":1776815418672,"version":"3.51.2"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Over the past decade, higher blood pressure (BP) variability and postural changes in BP have been associated with lower cognitive function. However, only one study has investigated the specific association between BP postural changes variability and brain health, showing a greater risk of dementia with higher systolic BP (SBP) postural changes variability. We aimed to investigate the association between BP postural changes variability and cognitive function in community\u2010dwelling older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Participants from the S.AGES (Sujets \u00c2GES) cohort underwent clinical examinations every 6 months during 3\u2009years. At each clinical visit, an orthostatic SBP ratio was calculated: (seated SBP\/standing SBP)\u00d7100. A similar method was used to compute an orthostatic diastolic BP ratio. Then, we assessed the visit\u2010to\u2010visit BP postural changes variability according to several indicators including coefficient of variation. Cognition was evaluated annually using the Mini\u2010Mental State Examination. Statistical analyses were performed with linear mixed models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included 2974 patients (mean age, 78\u2009years). After adjustment for demographics, cardiovascular risk factors and disease, seated SBP\/diastolic BP, and BP\u2010lowering treatment, visit\u2010to\u2010visit SBP postural changes variability was significantly associated with lower cognition (per 1\u2010SD increase in coefficient of variation: adjusted \u03b2=\u22120.15 [95% CI, \u22120.27 to \u22120.04],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.01). Similar results were found with visit\u2010to\u2010visit diastolic BP postural changes variability.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Visit\u2010to\u2010visit SBP and diastolic BP postural changes variability were associated with lower cognition. Further studies are needed to assess whether controlling orthostatic BP instability over time could help preserve cognitive function.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01065909.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039197","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:32:33Z","timestamp":1759915953000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Blood Pressure Postural Changes Variability Is Associated With Lower Cognition: The\u00a0S.AGES 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