{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:43:07Z","timestamp":1763991787220,"version":"3.45.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with sarcoidosis, cardiac involvement is a crucial prognostic factor leading to severe cardiovascular events. Mitral regurgitation (MR) predisposes patients to drug\u2010refractory heart failure; however, MR in patients with cardiac sarcoidosis (CS) has been scarcely investigated and its therapeutic approach remains unclear. This study aimed to investigate the clinical impact of transcatheter edge\u2010to\u2010edge repair in patients with CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with CS\u2010related ventricular functional MR were compared with those with other nonischemic cardiomyopathies in the OCEAN (Optimized Catheter Valvular Intervention)\u2010Mitral registry in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 1240 patients with nonischemic cardiomyopathy\u2010related ventricular functional MR, 40 (3.2%) had CS. Of these, 18 patients (45.0%) had immunosuppressive therapy. Twenty\u2010seven patients (67.5%) were New York Heart Association function class III\/IV. Patients with CS were more likely to be younger and female, had a higher prevalence of ventricular tachyarrhythmia and cardiac resynchronization therapy, and had a larger left ventricle with more severe MR than the others. At the procedure, 38 patients (95.0%) had devices placed at the central lesion. All patients with CS were successfully treated, leading to immediate improvement of cardiac output. At 1\u2010year follow\u2010up, 89.3% had MR \u22642+ and 40.0% had New York Heart Association function class I. Despite similar outcomes between groups, greater remnant MR and fatal arrhythmic events in those with CS may be due to inadequate reverse remodeling and ongoing left ventricle damage caused by inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter edge\u2010to\u2010edge repair is an effective heart failure treatment for patients with CS\u2010related MR; however, the drug\u2010 and cardiac device\u2010refractory cardiomyopathy in this population warrants careful management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.umin.ac.jp\/english\/\">www.umin.ac.jp\/english\/<\/jats:ext-link>\n                      ; Unique Identifier: UMIN000023653.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.039243","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T06:12:38Z","timestamp":1743055958000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Transcatheter Edge\u2010to\u2010Edge Repair in Patients With Cardiac Sarcoidosis: Insights From the OCEAN\u2010Mitral Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-9029","authenticated-orcid":false,"given":"Takashi","family":"Hiruma","sequence":"first","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]},{"name":"The University of Tokyo","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-109X","authenticated-orcid":false,"given":"Mike","family":"Saji","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]},{"name":"Toho University Faculty of Medicine","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Nanasato","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1819-2000","authenticated-orcid":false,"given":"Itaru","family":"Takamisawa","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, 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