{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:10:02Z","timestamp":1788876602780,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The coronary microcirculatory resistance index plays a crucial role in predicting patient prognosis. Coronary angiography\u2010based methods for assessing coronary microcirculatory function offer advantages such as simplicity and cost\u2010effectiveness. This study aimed to confirm the prognostic value of a novel angiographic microvascular resistance (AMR) index in patients undergoing transcatheter aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We prospectively included 335 patients with severe aortic stenosis who underwent transcatheter aortic valve replacement at Fuwai Hospital. The AMR was calculated based on coronary angiography performed before prosthetic valve implantation. Patients were divided into 2 groups based on an AMR cutoff value of 250: AMR \u2264250 and AMR &gt;250. The primary end point was major adverse cardiovascular events, defined as a composite of all\u2010cause mortality, readmission for heart failure, and myocardial infarction. At a median follow\u2010up of 40\u2009months (interquartile range [IQR], 25\u201350), AMR was significantly higher in patients who experienced the primary end point (257 [IQR, 186\u2013299] versus 226 [IQR, 177\u2013264];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), identifying it as an independent risk factor for major adverse cardiovascular events, all\u2010cause mortality, and new\u2010onset atrial fibrillation. Kaplan\u2010Meier analysis indicated that patients with AMR &gt;250 had significantly lower event\u2010free survival rates for major adverse cardiovascular events (62.9% versus 75.1%; hazard ratio, 1.94 [95% CI, 1.34\u20132.81]; log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), mainly driven by all\u2010cause death (75.7% versus 83.4%, log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.018). Subgroup analyses supported these findings for major adverse cardiovascular events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">AMR is an independent predictor of adverse clinical outcomes after transcatheter aortic valve replacement. An AMR &gt;250 can be used as a novel indicator for long\u2010term prognostic management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.039346","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:21:41Z","timestamp":1740986501000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Angiographic Microvascular Resistance Is an Independent Predictor of Adverse Clinical Outcomes After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-4566","authenticated-orcid":false,"given":"Wence","family":"Shi","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-4251","authenticated-orcid":false,"given":"Hongliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-9516","authenticated-orcid":false,"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changdong","family":"Guan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7803-0237","authenticated-orcid":false,"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014954"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13071989"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.01.036"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015133"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004088"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.01.005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2023-323461"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.12.232"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29592"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12111798"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(02)00225-6"},{"key":"e_1_3_2_17_2","first-page":"416","volume-title":"Applied Survival Analysis: Regression Modeling of Time to Event Data","author":"Hosmer DW","year":"1999","unstructured":"Hosmer DW, Lemeshow S, May S. 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