{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:56:01Z","timestamp":1789732561341,"version":"4.0.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,3]]},"abstract":"\n Background<\/jats:title>\n The optimal management strategy for in\u2010stent restenosis (ISR) remains unclear. We aimed to determine the safety and efficacy of percutaneous coronary intervention with XIENCE cobalt chromium everolimus\u2010eluting stents (EES) for treatment of ISR.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In the ILUMIEN IV (Optical Coherence Tomography Guided Coronary Stent Implantation Compared to Angiography: A Multicenter Randomized Trial in Percutaneous Coronary Intervention) trial, the 1\u2010year outcomes of all randomized patients with a single diffuse or multifocal single\u2010layer ISR lesion treated with EES were compared with a performance goal. The primary end point was target lesion failure, the composite of cardiac death, target vessel\u2010myocardial infarction, or ischemia\u2010driven target lesion revascularization. Outcomes in patients with a single EES\u2010treated ISR and non\u2010ISR lesion were also compared.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From May 2018 through December 2020, 247 patients with a single ISR lesion were treated with EES. Target lesion failure at 1 year occurred in 18 patients (7.4% [upper 1\u2010sided 97.5% CI, 11.5%]), which was lower than the predefined performance goal of 20% (\n P<\/jats:italic>\n <0.001). Compared with non\u2010ISR lesions treated with EES (n=2021), the postpercutaneous coronary intervention minimal stent area by optical coherence tomography was smaller in treated ISR lesions (5.0\u00b11.8\u2009mm\n 2<\/jats:sup>\n versus 5.6\u00b11.9\u2009mm\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n <0.001), but minimum stent expansion was similar (78.8\u00b118.0% versus 79.0\u00b116.9%;\n P<\/jats:italic>\n =0.87), as was 1\u2010year target lesion failure (7.4% versus 4.7%; hazard ratio, 1.58 [95% CI, 0.95\u20132.61];\n P<\/jats:italic>\n =0.07).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n XIENCE EES was safe and effective for treatment of single\u2010layer ISR. Compared with non\u2010ISR lesions, ISR lesions treated with EES had a smaller postpercutaneous coronary intervention minimal stent area although stent expansion and 1\u2010year target lesion failure rates were not different.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n ; Unique identifier: NCT03507777.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.039482","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:39:50Z","timestamp":1747910390000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and Efficacy of Cobalt Chromium Everolimus\u2010Eluting Stents for Treatment of In\u2010Stent Restenosis: An ILUMIEN IV Substudy"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-3197","authenticated-orcid":false,"given":"Ziad A.","family":"Ali","sequence":"first","affiliation":[{"name":"St. Francis Hospital and Heart Center","place":["Roslyn, USA"]},{"name":"Clinical Trials Center, Cardiovascular Research Foundation","place":["New York, USA"]},{"name":"New York Institute of Technology","place":["Old Westbury, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-3203","authenticated-orcid":false,"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Charit\u00e9; Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","place":["Berlin, Germany"]},{"name":"Berlin Institute of Health","place":["Berlin, Germany"]},{"name":"Deutsches Zentrum f\u00fcr Herz\u2010Kreislaufforschung","place":["Partner Site Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8447","authenticated-orcid":false,"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation","place":["New York, USA"]},{"name":"Columbia University Irving Medical Center","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-5732","authenticated-orcid":false,"given":"Doosup","family":"Shin","sequence":"additional","affiliation":[{"name":"St. Francis Hospital and Heart Center","place":["Roslyn, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-6497","authenticated-orcid":false,"given":"Koshiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"St. Francis Hospital and Heart Center","place":["Roslyn, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0247","authenticated-orcid":false,"given":"Mitsuaki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"St. Francis Hospital and Heart Center","place":["Roslyn, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Calligaris","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Maksoud","sequence":"additional","affiliation":[{"name":"Kansas Heart Hospital","place":["Wichita, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-4596","authenticated-orcid":false,"given":"Youssef S.","family":"Abdelwahed","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Charit\u00e9; Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","place":["Berlin, Germany"]},{"name":"Deutsches Zentrum f\u00fcr Herz\u2010Kreislaufforschung","place":["Partner Site Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-2853","authenticated-orcid":false,"given":"Paolo","family":"Canova","sequence":"additional","affiliation":[{"name":"Ospedale Papa Giovanni XXIII","place":["Bergamo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-945X","authenticated-orcid":false,"given":"Nieves","family":"Gonzalo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, IdISSC, 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