{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:10:01Z","timestamp":1788876601092,"version":"build-2803163510"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although intravenous thrombolysis (IVT) is safe and effective in populations with general stroke, its impact on cervical artery dissection\u2013related acute ischemic stroke (CeAD\u2010AIS) remains unclear. This retrospective study used the National Inpatient Sample to compare outcomes in patients with CeAD\u2010AIS treated with and without IVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We included adult patients with concurrent CeAD and AIS diagnoses (\n                      <jats:italic toggle=\"no\">International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      [\n                      <jats:italic toggle=\"no\">ICD\u201010<\/jats:italic>\n                      ], codes) hospitalized from 2016 to 2019. The primary outcome was home discharge; safety outcomes included inpatient death and intracerebral hemorrhage. We performed survey\u2010weighted multivariable logistic regressions comparing IVT versus no IVT, followed by interaction analyses to examine effect modifications based on age, medical history, stroke severity, carotid artery involvement, and endovascular treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Between 2016 and 2019, 1360 (12.1%) of 11\u2009285 patients with CeAD\u2010AIS received IVT. IVT\u2010treated patients had higher median National Institutes of Health Stroke Scale scores (median [interquartile range], 8 [4\u201317] versus 3 [1\u201311];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Adjusted analyses showed IVT was associated with higher odds of home discharge (adjusted odds ratio [OR], 1.40 [95% CI, 1.01\u20131.92];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.042), but not with inpatient death (adjusted OR, 1.29 [95% CI, 0.76\u20132.20];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.347) or intracerebral hemorrhage (adjusted OR, 0.69 [95% CI, 0.32\u20131.48];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.341). Stroke severity (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for interaction=0.001) and carotid artery involvement (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for interaction=0.021) significantly modified IVT's effect on home discharge, with IVT being associated with an increased likelihood of home discharge in patients with moderate to severe strokes (National Institutes of Health Stroke Scale score &gt;4) and carotid artery involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">IVT improves the likelihood of home discharge in patients with CeAD\u2010AIS without increasing the risk of inpatient death or intracerebral hemorrhage.<\/jats:p>\n                  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