{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:44:14Z","timestamp":1792511054553,"version":"4.5.0"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Social disconnection, including loneliness and social isolation, is associated with increased morbidity and death. However, its impact on the incidence and prognosis of atrial fibrillation (AF) remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The present prospective cohort study enrolled 418\u2009656 participants without AF and cardiovascular disease from the UK Biobank. A loneliness scale was constructed with 2 domains (loneliness feeling, inability to confide) and social isolation scale was constructed with 3 domains (living alone, lack of social support, and lack of social activity). We used a multistate model to analyze the impacts of the 2 scales on the progression from baseline to incident AF and subsequent major adverse cardiovascular events and further to death. Over a median follow\u2010up of 14.7\u2009years, 25\u2009539 participants developed incident AF, among whom 7283 developed incident major adverse cardiovascular events, and 5165 died. Social isolation and loneliness scales were associated with both a higher incidence and worse prognosis of AF, with hazard ratios per 1\u2010point increase of 1.06 (95% CI, 1.04\u20131.09) for the loneliness scale and 1.03 (95% CI, 1.02\u20131.05) for the social isolation scale for incident AF, and 1.12 to 1.14 for the loneliness scale (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and 1.12 to 1.27 for the social isolation scale (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) after AF development. Loneliness feeling and living alone may be important contributors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Loneliness and social isolation were both associated with a higher incidence and a worse prognosis of AF but to different extents. These observations highlight the importance of integrating social connection into the prevention and management of AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.039885","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:17Z","timestamp":1745625617000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Social Disconnection With the Incidence and Prognosis of Atrial Fibrillation: A Multistate Analysis"],"prefix":"10.1161","volume":"14","author":[{"given":"Yu","family":"Qiao","sequence":"first","affiliation":[{"name":"Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Kunming Medical University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ge","sequence":"additional","affiliation":[{"name":"University of Melbourne","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Liu","sequence":"additional","affiliation":[{"name":"Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Kunming Medical University","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9317-4672","authenticated-orcid":false,"given":"Guodong","family":"Niu","sequence":"additional","affiliation":[{"name":"Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Kunming Medical University","place":["Kunming, China"]},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-9179","authenticated-orcid":false,"given":"Yifang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research Institute, Peking University First Hospital","place":["Beijing, China"]},{"name":"Institute of Advanced Clinical Medicine, Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100786"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.4162"},{"key":"e_1_3_2_6_2","volume-title":"Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System","author":"National Academies of Sciences, Medicine, Division of Behavioral, Social Sciences, Medicine Division, Board on Behavioral, Sensory Sciences, Board on Health Sciences Policy, Committee on the Health, Medical Dimensions of Social Isolation, Loneliness in Older Adults","year":"2020","unstructured":"National Academies of Sciences, Medicine, Division of Behavioral, Social Sciences, Medicine Division, Board on Behavioral, Sensory Sciences, Board on Health Sciences Policy, Committee on the Health, Medical Dimensions of Social Isolation, Loneliness in Older Adults . 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