{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:12:37Z","timestamp":1781115157219,"version":"3.54.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The optimal systolic blood pressure (SBP) target for heart failure (HF) patients has not been established. Although the association between daytime SBP and prognosis has been reported in patients with HF, the prognostic impact of nighttime SBP remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We conducted continuous nighttime SBP measurements noninvasively using pulse transit time in 366 patients with HF (median age, 72\u2009years; male sex, 195), and followed up for cardiac events (HF hospitalization or cardiac death). Average values of nighttime pulse transit time \u2013based SBP were used in the present study. The patients were divided into tertile groups based on nighttime pulse transit time\u2013based SBP: high\u2010SBP group (median SBP, 136\u2009mm\u2009Hg; n=122), middle\u2010SBP group (median SBP, 117\u2009mm\u2009Hg; n=122), and low\u2010SBP group (median SBP, 100\u2009mm\u2009Hg; n=122).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              During a median follow\u2010up period of 1083\u2009days after nighttime pulse transit time\u2013based SBP measurement, 71 patients experienced a cardiac event. Kaplan\u2013Meier analysis showed the highest incidence of cardiac events in the low\u2010SBP group. Multivariate Cox proportional hazard analysis also showed that the lowest SBP tertile was associated with a higher risk of cardiac events compared with the highest SBP tertile as reference (hazard ratio, 2.100 [95% CI, 1.121\u20133.933];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.021).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Low nighttime SBP was associated with an increased cardiac event rate in patients with HF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039917","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:11:01Z","timestamp":1753099861000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Nighttime Systolic Blood Pressure Determined by Pulse Transit Time Predicts Cardiac Events in Patients With Heart\u00a0Failure"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1487-0479","authenticated-orcid":false,"given":"Naoto","family":"Ohashi","sequence":"first","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-6475","authenticated-orcid":false,"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-6617","authenticated-orcid":false,"given":"Akiomi","family":"Yoshihisa","sequence":"additional","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, Japan"]},{"name":"Fukushima Medical University School of Health Sciences","place":["Fukushima, 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Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-9345","authenticated-orcid":false,"given":"Takamasa","family":"Sato","sequence":"additional","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, Japan"]},{"name":"Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7614-8772","authenticated-orcid":false,"given":"Masayoshi","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Fukushima Medical University","place":["Fukushima, 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