{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:46:38Z","timestamp":1789415198912,"version":"build-2803163510"},"reference-count":74,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Prenatal per\u2010 and polyfluoroalkyl substance (PFAS) exposures may influence offspring blood pressure (BP), but long\u2010term studies in diverse populations remain limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Participants were from the Boston Birth Cohort. We measured PFAS in maternal plasma collected 24 to 72\u2009hours after delivery and extracted children's BP from medical records. We calculated age\u2010, sex\u2010, and height\u2010specific BP percentiles and defined elevated BP as systolic\/diastolic BP \u226590th percentile (ages 3 to &lt;13\u2009years) or \u2265120\/80\u2009mm\u2009Hg (ages 13 to &lt;18\u2009years). We used adjusted mixed\u2010effects linear and modified Poisson models to examine associations of PFAS with BP percentiles and elevated BP. We used linear spline mixed\u2010effects models to predict BP trajectories at ages 3 to 18\u2009years by PFAS levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We included 13\u2009404 BP measurements from 1094 children (median follow\u2010up: 12\u2009years [interquartile range, 9\u201315\u2009years]; 61% Black and 22% Hispanic). Overall, higher perfluorodecanoic acid (PFDeA), perfluorononanoic acid (PFNA), and perfluoroundecanoic acid (PFUnA) were associated with higher systolic BP percentile. The associations differed by child life stage, sex, race and ethnicity. For example, associations of PFDeA with systolic BP percentile were stronger in older (\u03b2\n              <jats:sub>3\u20135y<\/jats:sub>\n              =0.40; \u03b2\n              <jats:sub>6\u201312y<\/jats:sub>\n              =1.06; \u03b2\n              <jats:sub>13\u201318y<\/jats:sub>\n              =2.55), male (\u03b2\n              <jats:sub>male<\/jats:sub>\n              =1.51; \u03b2\n              <jats:sub>female<\/jats:sub>\n              =0.52), and Black (\u03b2\n              <jats:sub>Black<\/jats:sub>\n              =1.75; \u03b2\n              <jats:sub>Hispanic<\/jats:sub>\n              =0.45) children. In male children, each doubling of perfluoroheptanesulfonic acid (PFHpS)\u00a0was associated with a 9% higher risk of elevated BP at ages 6 to 12\u2009years and a 17% higher risk at 13 to 18\u2009years, with no increased risk at 3 to 5\u2009years. PFHpS was associated with a dose\u2010dependent divergence in BP trajectories beginning at age 13\u2009years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Prenatal exposures to certain PFAS were associated with offspring BP, with stronger associations in adolescents, male children, and Black children. Prenatal PFAS exposures may have intergenerational, long\u2010term, and latent hypertensive effects.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.039949","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:00:09Z","timestamp":1749751209000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal Per\u2010 and Polyfluoroalkyl Substance Exposures and Longitudinal Blood Pressure Measurements in Children Aged 3 to 18\u2009Years: Findings From a Racially and Ethnically Diverse US Birth Cohort"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8284-319X","authenticated-orcid":false,"given":"Zeyu","family":"Li","sequence":"first","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-8946","authenticated-orcid":false,"given":"Guoying","family":"Wang","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-1918","authenticated-orcid":false,"given":"Xiumei","family":"Hong","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-6747","authenticated-orcid":false,"given":"Tammy M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6669-6774","authenticated-orcid":false,"given":"Colleen","family":"Pearson","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-0157","authenticated-orcid":false,"given":"Jessie P.","family":"Buckley","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill","place":["Chapel Hill, USA"]},{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4451-302X","authenticated-orcid":false,"given":"Xiaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, USA"]},{"name":"Johns Hopkins University School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-0983","authenticated-orcid":false,"given":"Mingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2020.1733648"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.3310"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001209"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19455"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0055-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.23362"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2021.126223"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.04.380"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.117743"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4890"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706352"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-018-0094-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03477-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152565"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft248"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2020.09.008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.069"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116220"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030760"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.5888\/pcd16.180528"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/PN9.0000000000000011"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073730"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.11.063"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.109206"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10944"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.329"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP10125"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwz181"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c07970"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c06978"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041188"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.12.032"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106344"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP1330"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3917"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.181784"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-00717-x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1289\/EHP12597"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.06.273"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-023-01023-5"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.112971"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/EE9.0000000000000289"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2024.114427"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.127691"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-020-00656-0"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-environ-082508-094348"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c09716"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13353"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51187-4"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.10.002"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0100-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106853"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131722"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22760"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0470-x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108014"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-020-00279-0"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(98)00178-2"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2015"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119376"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa044"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20139"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.107748"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.612320"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq379"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1199"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-023-01241-9"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22695"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/eep\/dvac017"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.109144"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/es301168c"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/es501811k"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2289"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.039949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:37:05Z","timestamp":1756359425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.039949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":74,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6,17]]}},"alternative-id":["10.1161\/JAHA.124.039949"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.039949","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"2024-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e039949"}}