{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:19:08Z","timestamp":1792153148921,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Pulmonary embolism (PE) can be a life\u2010threatening condition. Endovascular treatment is emerging as a promising treatment to restore hemodynamic stability and reverse right ventricular (RV) dysfunction in PE; however, more studies are needed to elucidate the effects on the right ventricle after endovascular treatment. This analysis reports the effects of computer assisted vacuum thrombectomy on RV function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Eligible patients for the single\u2010arm, prospective, international, multicenter STRIKE\u2010PE (A Prospective, Multicenter Study of the Indigo Aspiration System Seeking to Evaluate the Long\u2010Term Safety and Outcomes of Treating Pulmonary Embolism) cohort study are adults with acute PE with symptoms for \u226414\u2009days and an RV\/left ventricular ratio of \u22650.9 who are treated with computer assisted vacuum thrombectomy. Reported here are periprocedural and RV outcomes of the initial 300 patients of STRIKE\u2010PE, to provide insights into effects on RV function after computer assisted vacuum thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients were classified with high\u2010risk (5.7%), intermediate\u2010high\u2010risk (84.7%), or intermediate\u2010low\u2010risk (9.7%) PE. Median thrombectomy time was 30 minutes. Mean on\u2010table systolic pulmonary artery pressure decreased from 51.7\u2009mm Hg to 41.3\u2009mm Hg, a 19.1% reduction (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The change in mean RV\/left ventricular ratio from baseline to 48 hours postprocedure (primary effectiveness end point) was a decrease from 1.40 to 0.99, a 26.8% reduction (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Clinical parameters and echocardiographic measures of right heart strain improved from baseline to 48 hours postprocedure (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The rate of composite major adverse events within 48 hours postprocedure (primary safety end point) was 2.0%. Median Borg dyspnea scale at rest decreased from 4.0 at baseline to 0.5 at discharge (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">This interim analysis demonstrates that computer assisted vacuum thrombectomy safely and expeditiously improves hemodynamic status, RV function, and perceived dyspnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration: URL<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT04798261.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.039975","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:05:29Z","timestamp":1756465529000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Periprocedural Results and Right Ventricular Outcomes of Computer Assisted Vacuum Thrombectomy Treatment of Acute Pulmonary Embolism: Interim Analysis of 300 Patients From the STRIKE\u2010PE Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8108-520X","authenticated-orcid":false,"given":"John M.","family":"Moriarty","sequence":"first","affiliation":[{"name":"UCLA Health","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Schiro","sequence":"additional","affiliation":[{"name":"Miami Cardiac & Vascular Institute","place":["Miami, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-8475","authenticated-orcid":false,"given":"Suhail Y.","family":"Dohad","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"Tamaddon","sequence":"additional","affiliation":[{"name":"Piedmont Augusta","place":["Augusta, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8592-9967","authenticated-orcid":false,"given":"Hugh C.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Florida \u2013 Shands Hospital","place":["Gainesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-9807","authenticated-orcid":false,"given":"David M.","family":"Shavelle","sequence":"additional","affiliation":[{"name":"MemorialCare Heart & Vascular Institute","place":["Long Beach, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.","family":"Chrysant","sequence":"additional","affiliation":[{"name":"INTEGRIS Baptist Medical Center \/ INTEGRIS Cardiovascular Physicians","place":["Oklahoma City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A.","family":"Iliadis","sequence":"additional","affiliation":[{"name":"Cooper University Hospital","place":["Camden, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1366-3906","authenticated-orcid":false,"suffix":"II","given":"David J.","family":"Dexter","sequence":"additional","affiliation":[{"name":"Sentara Vascular Specialists","place":["Norfolk, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Ciampi Dopazo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de las Nieves in Granada","place":["Granada, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-4960","authenticated-orcid":false,"given":"Andrew","family":"Holden","sequence":"additional","affiliation":[{"name":"Auckland University School of Medicine","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-8382","authenticated-orcid":false,"given":"Frances M.","family":"West","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University Hospital","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-6495","authenticated-orcid":false,"given":"Brent","family":"Keeling","sequence":"additional","affiliation":[{"name":"Emory University Hospital Midtown","place":["Atlanta, 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