{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:21:41Z","timestamp":1792686101885,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"jah311067-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Transcatheter aortic valve replacement (TAVR) is increasingly used in patients with aortic stenosis; however, the optimal postoperative anticoagulation therapy for patients with atrial fibrillation (AF) remains controversial. We aimed to investigate the association between anticoagulant therapy selection and outcomes in patients with AF after TAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311067-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We retrospectively analyzed patients with AF who underwent TAVR. Patients were divided into 2 groups according to the anticoagulant therapy administered 3\u2009months after the index TAVR (direct oral anticoagulant [DOAC] and vitamin K antagonist [VKA] groups). The primary end points were thromboembolic and major bleeding events after a landmark period of 3\u2009months. We analyzed the association between oral anticoagulants and outcomes using propensity score matching.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311067-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among 47\u2009883 patients who underwent TAVR between April 2014 and March 2021, 10\u2009041 had a history of AF and anticoagulant therapy. Of these, 8191 patients were prescribed a DOAC, while 1850 received a VKA. Before matching, the thromboembolic event rate was 2.2 per 100 person\u2010years in the DOAC group and 3.6 per 100 person\u2010years in the VKA group, whereas the bleeding event rates were 7.1 and 10.0 per 100 person\u2010years, respectively. After matching, VKA was associated with higher risks of thromboembolic events (hazard ratio [HR], 1.46 [95% CI, 1.12\u20131.91];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.004) and bleeding events (HR, 1.21 [95% CI, 1.03\u20131.42];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.016).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311067-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">DOAC use in patients with AF who undergo TAVR may be preferable to VKA use in a real\u2010world clinical setting.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040030","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:02:18Z","timestamp":1750723338000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Anticoagulation Therapy for Atrial Fibrillation After Transcatheter Aortic Valve Replacement: National Database Insights"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3120-218X","authenticated-orcid":false,"given":"Koki","family":"Takegawa","sequence":"first","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]},{"name":"Institute of Science Tokyo","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-7835","authenticated-orcid":false,"given":"Koshiro","family":"Kanaoka","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Osaka, Japan"]},{"name":"Nara Medical University","place":["Kashihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-2864","authenticated-orcid":false,"given":"Yoshitaka","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Sakurabashi\u2010Watanabe Hospital","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-6104","authenticated-orcid":false,"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Institute of Science Tokyo","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-3925","authenticated-orcid":false,"given":"Yuichi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Nara Medical University","place":["Kashihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Myojin","sequence":"additional","affiliation":[{"name":"Nara Medical University","place":["Kashihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Noda","sequence":"additional","affiliation":[{"name":"Nara Medical University","place":["Kashihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Nara Medical University","place":["Kashihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-0508","authenticated-orcid":false,"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Suita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_3_2_3_2","first-page":"e35","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease. A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Developed in collaboration with and endorsed by the American Association for Thoracic Surgery, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons","volume":"143","author":"Otto CM","year":"2021","unstructured":"Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP III, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, et\u00a0al. 2020 ACC\/AHA guideline for the management of patients with valvular heart disease. A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Developed in collaboration with and endorsed by the American Association for Thoracic Surgery, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons. Circulation. 2021;143:e35\u2013e71.","journal-title":"Circulation"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae043"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1032"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911425"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915152"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac242"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059512"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.11.038"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2023.07.012"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.14326\/abe.11.203"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001301"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.08.033"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.595"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.06.020"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-21-01048"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023561"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.07.014"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.08.076"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.09.013"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-22-0093"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy861"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.046"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.04.014"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.010097"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2017815"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62177-1"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0049-1"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.040030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:57:04Z","timestamp":1753876624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.040030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1161\/JAHA.124.040030"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.040030","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040030"}}