{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:10Z","timestamp":1787018110520,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4,15]]},"abstract":"\n Background<\/jats:title>\n \n Intracranial anterior circulation large artery occlusion (AC\u2010LAO) is a predominant cause of ischemic stroke. Although collateral circulation plays a critical role in stroke outcomes, the genetic and environmental factors affecting collateral development are not fully understood. This study aimed to elucidate the associations between\n Rabep2<\/jats:italic>\n gene polymorphisms, collateral circulation, and both short\u2010 and long\u2010term prognoses in patients with anterior circulation large artery occlusion.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We recruited 449 patients with anterior circulation large artery occlusion with cerebral infarction. Collateral circulation was assessed using single\u2010phase computed tomography angiography, and stroke outcomes were evaluated at 1\u2009month and 1\u2009year using the modified Rankin Scale. A subset of 180 patients underwent genetic analysis for\n Rabep2<\/jats:italic>\n polymorphisms. Multivariable logistic regression was employed to identify predictors of short\u2010term and long\u2010term outcomes. Enhanced collateral circulation (\n P<\/jats:italic>\n <0.001), lower high\u2010density lipoprotein levels (\n P<\/jats:italic>\n =0.019), and the absence of complications (\n P<\/jats:italic>\n <0.001) were significantly correlated with favorable short\u2010term outcomes. In the long term, age (\n P<\/jats:italic>\n =0.039) and diabetes (\n P<\/jats:italic>\n =0.006) were independent predictors of poor prognosis, whereas complications demonstrated a protective effect (\n P<\/jats:italic>\n =0.016). The rs11645302 polymorphism of\n Rabep2<\/jats:italic>\n was linked to poorer collateral circulation among patients with the CC genotype (odds ratio [OR], 0.498 [95% CI, 0.270\u20130.918],\n P<\/jats:italic>\n =0.025).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Collateral circulation, high\u2010density lipoprotein levels,\n Rabep2<\/jats:italic>\n gene polymorphisms, age, and diabetes are significant predictors of outcomes in patients with anterior circulation large artery occlusion. These findings underscore the potential to integrate genetic and vascular factors into personalized risk stratification and therapeutic strategies for ischemic stroke.\n <\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/www.ClinicalTrials.gov<\/jats:ext-link>\n ; Unique Identifier: NCT04091412.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.040032","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:03:53Z","timestamp":1744265033000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Collateral Circulation and\n Rabep2<\/i>\n Polymorphisms in Large Artery Occlusion: Impacts on Short\u2010 and Long\u2010Term Prognosis"],"prefix":"10.1161","volume":"14","author":[{"given":"Kun","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luji","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Bu","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandi","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8604-904X","authenticated-orcid":false,"given":"Xiaoyun","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60399-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020140"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241270480"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00228-X"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.046056"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231194956"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20924107"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.09.015"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.06.013"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241242954"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00575-5"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7826"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae576"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035609"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5721167"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00369-7"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03806-w"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20918816"}],"container-title":["Journal of the American Heart 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