{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:07:28Z","timestamp":1790633248832,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"\n Background<\/jats:title>\n Supervised treadmill exercise improves walking performance in people with lower extremity peripheral artery disease, but benefits are not immediate. This study identified the time course of attaining meaningful improvement in 6\u2010minute walk distance and patient\u2010reported outcome measures during a 6\u2010month supervised exercise intervention in people with peripheral artery disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Participants with peripheral artery disease were randomized to supervised treadmill exercise 3 time weekly or a nonexercise control group for 6\u2009months. Six\u2010minute walk distance (large clinically important difference: 20 meters) and the Walking Impairment Questionnaire distance score (0\u2013100 scale, 100 is best, clinically important difference: 5 points) were measured at the 6\u2010week, 12\u2010week, and 26\u2010week follow\u2010up using a mixed\u2010effects model for repeated measures.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 210 randomized participants (mean age, 67.0\u00b18.6\u2009years, 82 [39%] women, 141 [66%] Black), 200 (95%) completed at least 1 follow\u2010up visit. Compared with controls, supervised exercise significantly improved 6\u2010minute walk distance by 13.0\u2009m (\n P<\/jats:italic>\n =0.049) at the 6\u2010week, 31.8\u2009m (\n P<\/jats:italic>\n <0.001) at the 12\u2010week, and 33.9\u2009m (\n P<\/jats:italic>\n <0.001) at the 26\u2010week follow\u2010up. Compared with controls, supervised exercise increased the Walking Impairment Questionnaire distance score by +2.63 (\n P<\/jats:italic>\n =0.37) at the 6\u2010week, +6.59 (\n P<\/jats:italic>\n =0.049) at the 12\u2010week, and +2.37 (\n P<\/jats:italic>\n =0.49) at the 26\u2010week follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In people with peripheral artery disease, >6\u2009weeks of supervised treadmill exercise was necessary to attain a large meaningful gain in 6\u2010minute walk, and large meaningful gains were measurable by week 12 of supervised exercise. Meaningful improvement in participant reported walking ability was first observed at the 12\u2010week follow\u2010up, but this statistically significant benefit was gone by the 26\u2010week follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT01408901.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.040058","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:41:08Z","timestamp":1757133668000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Duration of Supervised Exercise Necessary for Meaningful Improvement in Peripheral Artery Disease"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-7619","authenticated-orcid":false,"given":"Mary M.","family":"McDermott","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-2020","authenticated-orcid":false,"given":"Dongxue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-9490","authenticated-orcid":false,"given":"Lihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-9244","authenticated-orcid":false,"given":"Tamar","family":"Polonsky","sequence":"additional","affiliation":[{"name":"University of Chicago","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-1613","authenticated-orcid":false,"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"National Institute on Aging","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-8953","authenticated-orcid":false,"given":"Karen J.","family":"Ho","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine","place":["Chicago, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-4205","authenticated-orcid":false,"given":"Melina R.","family":"Kibbe","sequence":"additional","affiliation":[{"name":"University of Virginia Health","place":["Charlottesville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-7263","authenticated-orcid":false,"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-9661","authenticated-orcid":false,"given":"Michael H.","family":"Criqui","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-0169","authenticated-orcid":false,"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Stanford University","place":["Palo Alto, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001329"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2126"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.007953"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17437"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2013.09.011"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1078-5884(97)80102-5"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-1166(199806)13:6<368::aid-gps775>3.0.co;2-9"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.007002"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2536"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18762599"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.03.052"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199104000-00003"},{"key":"e_1_3_1_15_2","first-page":"142","article-title":"Evaluation of walking impairment by questionnaire in patients with peripheral arterial disease","author":"Regensteiner J.","year":"1990","unstructured":"Regensteiner J. Evaluation of walking impairment by questionnaire in patients with peripheral arterial disease. J Vasc Med Biol 1990. p. 142\u2013152.","journal-title":"J Vasc Med Biol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.108640"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X9600100112"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.13.1599"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.05.058"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.1077"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.11.123"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.040058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T03:58:04Z","timestamp":1758167884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.040058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":20,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9,16]]}},"alternative-id":["10.1161\/JAHA.124.040058"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.040058","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]},"assertion":[{"value":"2024-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040058"}}