{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:45:55Z","timestamp":1793641555426,"version":"4.5.1"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Aortic valve calcification (AVC) is the primary process leading to aortic stenosis. We examined whether polygenic risk scores (PRS) are associated with AVC beyond traditional atherosclerotic cardiovascular disease risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included 6812 participants in MESA (Multi\u2010Ethnic Study of Atherosclerosis) with computed tomography\u2010measured AVC at Visit 1. Using previously published PRS we calculated weighted PRS, standardized within each ancestry group. The cross\u2010sectional association per 1 SD higher PRS with AVC &gt;0 was examined using multivariable logistic regression modeling with Bonferroni correction. The mean age was 62\u2009years old, 53% were female, and 913 (13.4%) had AVC &gt;0 at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The PRS for coronary artery disease (hazard ratio [HR], 1.16 [95% CI, 1.07\u20131.26]), systolic blood pressure (HR, 1.1 [95% CI, 1.020\u20131.2]), low\u2010density lipoprotein cholesterol (HR, 1.16 [95% CI, 1.06\u20131.25]), and lipoprotein(a) (HR, 1.11 [95% CI, 1.02\u20131.20]) were significantly associated with AVC, whereas the other PRS including coronary artery calcium (HR, 1.02 [95% CI, 0.94\u20131.10]) and C\u2010reactive protein (HR, 0.97 [95% CI, 0.89\u20131.05]) were not. In sex\u2010stratified analyses, the PRS for coronary artery disease, low\u2010density lipoprotein cholesterol, and lipoprotein(a) were significantly associated with AVC &gt;0 for both sexes (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05), whereas the systolic blood pressure PRS was borderline significant for women (HR, 1.10 [95% CI, 0.97\u20131.25]) and significant for men (HR, 1.11 [95% CI 1.00\u20131.24]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our results confirm the role of atherogenic lipids in the pathogenesis of AVC and suggest that systolic blood pressure and the genetic risk factors for CAD are also important risk factors. The lack of association for the coronary artery calcium PRS with AVC &gt;0 strongly suggests significant differences exist in the calcification pathways for AVC and coronary artery calcium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040064","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:07:47Z","timestamp":1778058467000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Polygenic Risk Scores With Aortic Valve Calcium: The Multi\u2010Ethnic Study of Atherosclerosis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5914-0735","authenticated-orcid":false,"given":"Seamus P.","family":"Whelton","sequence":"first","affiliation":[{"name":"Johns Hopkins School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-0651","authenticated-orcid":false,"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-9245","authenticated-orcid":false,"given":"Clary","family":"Clish","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard","place":["Cambridge, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-2119","authenticated-orcid":false,"given":"Alexis C.","family":"Wood","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-4370","authenticated-orcid":false,"given":"Kent D.","family":"Taylor","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9683","authenticated-orcid":false,"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":false,"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[{"name":"Harbor\u2010UCLA Medical Center Research and Education Institute","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1938-9679","authenticated-orcid":false,"given":"Natalie","family":"Marrero","sequence":"additional","affiliation":[{"name":"Harbor\u2010UCLA Medical Center Research and Education Institute","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-7189","authenticated-orcid":false,"given":"George","family":"Thanassoulis","sequence":"additional","affiliation":[{"name":"McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-5204","authenticated-orcid":false,"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[{"name":"Johns Hopkins School of Medicine","place":["Baltimore, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5068","authenticated-orcid":false,"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-1723","authenticated-orcid":false,"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[{"name":"The Lundquist Institute for Biomedical Innovation at Harbor\u2010UCLA Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.066"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1313875"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.02.013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","unstructured":"Marrero N Jha K Razavi AC Boakye E Anchouche K Dzaye O Budoff MJ Tsai MY Shah SJ Rotter JI et\u00a0al. 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