{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:13:10Z","timestamp":1792818790699,"version":"4.5.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec id=\"jah311113-sec-0001\" xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sarcopenia, an age\u2010related condition, has an unclear association with cardiovascular disease (CVD) risk. We aimed to analyze whether sarcopenia and its individual components are associated with new\u2010onset CVD in middle\u2010aged and older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah311113-sec-0002\" xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Data were derived from the China Health and Retirement Longitudinal Study, with sarcopenia defined by the Asian Working Group for Sarcopenia 2019 criteria. The primary outcome was composite CVD, comprising heart disease and stroke. Multivariable Cox proportional hazards regression analysis and Fine\u2013Gray subdistribution hazards models were used to calculate hazard ratios (HRs), subdistribution hazard ratios (SHRs), and 95% CIs. A total of 10\u2009649 participants (mean age 64.5\u00b110.7\u2009years, 47.6% male) were included. During mean follow\u2010up of 4.60\u00b11.06\u2009years, there were 1649 (15.5%) cases of new\u2010onset CVD. Possible sarcopenia was linked to increased new\u2010onset composite CVD risk (HR, 1.21 [95% CI, 1.06\u20131.37]; SHR, 1.20 [95% CI, 1.05\u20131.35]), whereas sarcopenia and severe sarcopenia showed no association. Restricted cubic spline analysis revealed that 5\u2010time chair stand test (5\u2010CST) was associated with new\u2010onset composite CVD, with significant sex\u2010specific interaction (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2010for\u2010interaction=0.001). Compared with 5\u2010CST\u22649.0 s, higher risk of new\u2010onset composite CVD was observed in men for 9.0 s&lt;5\u2010CST\u226415.0 s (HR, 1.36 [95% CI, 1.16\u20131.59]; SHR, 1.34 [95% CI, 1.15\u20131.56]) and 5\u2010CST&gt;15.0 s (HR, 2.19 [95% CI, 1.65\u20132.90]; SHR, 2.00 [95% CI, 1.53\u20132.63]). Among women, 5\u2010CST&gt;8.5 s had higher risk of new\u2010onset composite CVD compared with 5\u2010CST\u22648.5 s (HR, 1.26 [95% CI, 1.09\u20131.45]; SHR, 1.25 [95% CI, 1.09\u20131.43]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"jah311113-sec-0003\" xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">Possible sarcopenia was associated with increased risk of new\u2010onset composite CVD, suggesting that progression to definite sarcopenia may not parallel cardiovascular risk. Longer 5\u2010CST was linked to higher risk of new\u2010onset composite CVD, with sex\u2010specific association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040099","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:52:35Z","timestamp":1750225955000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Associations of Sarcopenia and Its Components With Cardiovascular Risk: Five\u2010Year Longitudinal Evidence From China Health and Retirement Longitudinal Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-6286","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"first","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-2019","authenticated-orcid":false,"given":"Ziyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-8915","authenticated-orcid":false,"given":"Ying","family":"Gue","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"McDowell","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"Liverpool John Moores University","place":["Liverpool, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-3452","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coleen","family":"Ditchfield","sequence":"additional","affiliation":[{"name":"Whiston Hospital, Mersey and West Lancashire Teaching Hospitals NHS Trust","place":["Prescot, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-1428","authenticated-orcid":false,"given":"Muath","family":"Alobaida","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"University of Liverpool","place":["United Kingdom"]},{"name":"Prince Sultan Bin Abdulaziz College for Emergency Medical Services, King Saud University","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital","place":["Liverpool, United Kingdom"]},{"name":"the First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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