{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:47:06Z","timestamp":1789264026438,"version":"build-2803163510"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Recommendations for beta blockers in preventing aortic dissection (AD) and improving postdissection survival in nonsyndromic patients with hypertension are based on limited evidence.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This nationwide, population\u2010based study combined a nested case\u2013control and historical cohort design. Using Danish health care registries, all hospitalized adult patients with AD from 1996 to 2016 were identified and validated. Patients with bicuspid aortic valves or connective tissue disorders were excluded. In the case\u2013control analysis, 1657 validated AD cases were matched 1:10 (\u00b11) with 16\u2009139 controls with hypertension based on age, sex, index date, and cumulative antihypertensive drug use. Long\u2010term beta blocker use was defined as \u22652000 defined daily doses (DDD). In the cohort analysis, 2120 validated survivors of AD were followed for 5\u2009years to assess postdissection mortality stratified by beta blocker use.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Long\u2010term beta blocker use was associated with increased odds of AD type A (adjusted odds ratio [aOR], 1.7 [95% CI, 1.3\u20132.3]) and AD type B (aOR, 3.7 [95% CI, 2.7\u20135.2]) compared with never\u2010users. A dose\u2010dependent risk increase was observed for AD type B (aOR, 1.4 [95% CI, 0.8\u20132.2] for DDD 100\u2013199; aOR, 3.9 [95% CI, 1.6\u20139.8] for DDD \u226510\u2009000). Beta blocker use was associated with higher 5\u2010year all\u2010cause mortality in survivors of AD type A (adjusted hazard ratio [aHR], 1.5 [95% CI, 0.99\u20132.23]) and AD type B (aHR, 1.5 [95 %CI, 1.0\u20132.3]) compared with never\u2010users.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Beta blocker use did not reduce AD risk or improve outcomes in survivors of AD compared with other antihypertensive agents. Although clinically relevant data as aortic diameters and blood pressure were not available, these findings challenge current clinical practice and highlight the need for randomized trials.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040149","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T23:44:07Z","timestamp":1749685447000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Beta Blockers as Primary and Secondary Prevention for Aortic Dissections in Nonsyndromic Patients With Hypertension"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-4176","authenticated-orcid":false,"given":"Mads","family":"Liisberg","sequence":"first","affiliation":[{"name":"University Hospital Odense","place":["Odense, Denmark"]},{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-4488","authenticated-orcid":false,"given":"Jes S.","family":"Lindholt","sequence":"additional","affiliation":[{"name":"University Hospital Odense","place":["Odense, Denmark"]},{"name":"Odense University Hospital","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-5181","authenticated-orcid":false,"given":"Katrine L.","family":"Larsen","sequence":"additional","affiliation":[{"name":"University Hospital Odense","place":["Odense, Denmark"]},{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1285-4826","authenticated-orcid":false,"given":"Axel C. 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