{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:13:03Z","timestamp":1789416783200,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"\n Background<\/jats:title>\n The comparison of outcomes of mini\u2010crush (MCT) versus double kissing crush (DKC) techniques for complex left main bifurcation (LMB) lesions is still lacking. This investigation aimed to assess the long\u2010term outcomes of patients who underwent MCT or DKC for LMB disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n From 2014 to 2024, patients who underwent percutaneous coronary intervention for complex LMB lesions were retrospectively collected. The primary end point was major adverse cardiac events as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization during follow\u2010up. The secondary end point was measured as major adverse cardiovascular and cerebral events including all\u2010cause death, target vessel revascularization, target vessel myocardial infarction, stent thrombosis, and stroke.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This large\u2010scale multicenter (n=13) observational study included a total of 531 consecutive patients (men: 405 [76.3%], mean age: 63.16\u00b111.26\u2009years) with complex LMB lesions who underwent percutaneous coronary intervention. The initial revascularization strategy was MCT in 313 (59%) patients and DKC in 218 (41%) patients. The number of balloons used (5.91\u00b11.53 versus 6.72\u00b11.70,\n P<\/jats:italic>\n <0.001) and procedure time (66.60\u00b124.20 versus 72.97\u00b119.97\u2009minutes,\n P<\/jats:italic>\n <0.001) were notably lower in the MCT group. In the overall population, the long\u2010term major adverse cardiac events (hazard ratio [HR], 0.704;\n P<\/jats:italic>\n =0.169) and major adverse cardiovascular and cerebral events (HR, 0.660;\n P<\/jats:italic>\n =0.079) did not differ in individuals with complex LMB lesions treated with MCT and DKC. Other end points were also comparable between the 2 groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In complex LMB lesions, risk\u2010adjusted major adverse cardiac events and major adverse cardiovascular and cerebral events rates were comparable between both techniques, with a nonsignificant trend favoring DKC at long\u2010term follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique Identifier: NCT06546748.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.040166","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:37:43Z","timestamp":1747816663000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["DK\u2010Crush or Mini\u2010Crush Stenting for Complex Left Main Bifurcation Lesions: The Multicenter EVOLUTE\u2010CRUSH LM 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outcomes of different two\u2010stent techniques with second\u2010generation drug\u2010eluting stents for unprotected left Main bifurcation disease: insights from the FAILS\u20102 study","volume":"30","author":"Pavani M","year":"2018","unstructured":"Pavani M, Conrotto F, Cerrato E, D'Ascenzo F, Kawamoto H, N\u00fa\u00f1ez\u2010Gil IJ, Pennone M, Garbo R, Tomassini F, Colombo F, et\u00a0al. Long\u2010term outcomes of different two\u2010stent techniques with second\u2010generation drug\u2010eluting stents for unprotected left Main bifurcation disease: insights from the FAILS\u20102 study. 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