{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:21:57Z","timestamp":1790144517773,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Lower left atrial (LA) function may precede LA enlargement and contribute to mitral regurgitation (MR). We examined the association of LA reservoir strain (a measure of LA function) with MR in the ARIC (Atherosclerosis Risk in Communities) study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed ARIC participants with echocardiograms at Visits 5 (2011\u20132013) and 7 (2018\u20132019). LA reservoir strain was measured at Visit 5. MR was diagnosed by echocardiography. The cross\u2010sectional association was assessed at Visit 5, and the prospective association was examined through Visit 7 using multivariable logistic regression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In the cross\u2010sectional analysis (n=4689, mean age 75.2\u00b15.0\u2009years, 60.2% female, 19.9% Black), 1927 participants (41.1%) had prevalent MR. Each 1\u2010SD (7.53%) lower LA reservoir strain was associated with higher odds of prevalent MR (odds ratio [OR], 1.12 [95% CI, 1.04\u20131.20]). In the prospective analysis (n=1480, mean age 73.5\u00b14.2\u2009years, 54.9% female, 22.6% Black), 409 participants developed MR. A 1\u2010SD (6.71%) lower LA reservoir strain was associated with higher odds of incident MR (OR, 1.18 [95% CI, 1.04\u20131.34]); the association was partially attenuated after adjusting for post\u2010Visit 5 heart failure and atrial fibrillation (OR, 1.14 [95% CI, 1.00\u20131.30]) and further attenuated after adjusting for LA volume index from Visit 5 (OR, 1.11 [95% CI, 0.98\u20131.27]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">LA reservoir strain is associated with prevalent and incident MR in older adults. The association between lower LA reservoir strain and incident MR may be partially explained by LA enlargement, apart from atrial fibrillation and heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040175","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:28:42Z","timestamp":1754998122000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-2560","authenticated-orcid":false,"given":"Chunxiao","family":"Zhang","sequence":"first","affiliation":[{"name":"University of Minnesota","place":["Minneapolis, 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Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Wake Forest University","place":["Winston\u2010Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-9597","authenticated-orcid":false,"given":"Scott D.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-4451","authenticated-orcid":false,"given":"Amil M.","family":"Shah","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-814X","authenticated-orcid":false,"given":"Lin Yee","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School","place":["Minneapolis, 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