{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:48:20Z","timestamp":1769827700353,"version":"3.49.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although the association between remnant cholesterol (RC) and cognitive impairment has been reported, the association of RC with cognitive decline remains scarce. Also, the role of lipid\u2010lowering therapy in the association is unclear. The study aimed to examine the longitudinal associations of RC with cognitive decline by lipid\u2010lowering drug use during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The study used data from Wave 2 (2004\u20132005) to Wave 8 (2016\u20132017) of the ELSA (English Longitudinal Study of Ageing). Global cognitive functions at baseline (Wave 2) and during the follow\u2010up (Waves 3\u20138) were assessed by integrating 3 cognitive domains: memory capacity, semantic fluency, and orientation. Multivariate\u2010adjusted linear mixed models were employed to examine the longitudinal associations, with results presented as\n                      <jats:italic toggle=\"no\">\u03b2<\/jats:italic>\n                      (95% CI) in SD\/year. Of the 5053 participants ultimately included, 55.4% were female and the mean age (SD) was 65.7 (9.3) years. Per 1\u2009mmol\/L increment in RC was significantly associated with a faster rate of cognitive decline (\n                      <jats:italic toggle=\"no\">\u03b2<\/jats:italic>\n                      =\u22120.010 SD\/year [95% CI \u22120.019 to \u22120.001]). Furthermore, we observed that association pattern between RC and cognitive decline only in the non\u2010lipid\u2010lowering drug group (\n                      <jats:italic toggle=\"no\">\u03b2<\/jats:italic>\n                      =\u22120.019 SD\/year [95% CI, \u22120.031 to \u22120.007]) but not in the lipid\u2010lowering drug group (\n                      <jats:italic toggle=\"no\">\u03b2<\/jats:italic>\n                      =0.007 SD\/year [95% CI, \u22120.006 to 0.020]), with a significant interaction (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.015). Similar findings were observed for the 3 cognitive domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Higher baseline RC levels were associated with steeper cognitive decline. The use of lipid\u2010lowering drugs might mitigate this decline. These findings underscore the importance of early RC monitoring and proactive management with lipid\u2010lowering drugs in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040211","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T06:51:51Z","timestamp":1742971911000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Association of Remnant Cholesterol With Cognitive Decline Varies by Lipid\u2010Lowering Drugs: A Population\u2010Based Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-2816","authenticated-orcid":false,"given":"Jianian","family":"Hua","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-5658","authenticated-orcid":false,"given":"Jianye","family":"Dong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-982X","authenticated-orcid":false,"given":"Haibin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-974X","authenticated-orcid":false,"given":"Qingmei","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2018.06.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2468-2667(21)00249-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30367-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146554"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/jad-160826"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa140"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.07.757"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100963"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab432"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2511"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.121.012615"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1069076"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1458970"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1332767"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01729-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2666-7568(24)00112-0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R700001-JLR200"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.115.306768"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.12.039"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.556159"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.03.012"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21983-w"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010069"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys168"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02755.x"},{"key":"e_1_3_2_28_2","first-page":"34","volume-title":"Health Survey for England 2004, Methodology and Documentation","author":"Graig R","year":"2006","unstructured":"Graig R, Deverill C, Pickering K. 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