{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:02:36Z","timestamp":1788912156018,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke) trial found no benefit of anticoagulation for preventing recurrent stroke in patients with atrial cardiopathy. Data on AF monitoring across trial sites may provide context for the findings and knowledge about the current standard of care for poststroke monitoring.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">At study visits, sites reported any preceding use of prolonged heart rhythm monitoring, classified as either external ambulatory monitors or implantable loop recorders. We used relative risk regression, least absolute shrinkage and selection operator (LASSO) regression, and survival analysis to explore patient characteristics associated with monitoring, the association between monitoring and AF detection, and the interaction between monitoring and study treatment effect on recurrent stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Of 1633 patients with monitoring data, 957 (58.6%) underwent prolonged monitoring: 567 (34.7%) external ambulatory monitor, 479 (29.3%) implantable loop recorder, and 89 (5.5%) both. The strongest predictors of monitoring were Hispanic ethnicity (standardized LASSO coefficient, \u22120.19 [risk ratio (RR), 0.66]), National Institutes of Health Stroke Scale score (LASSO, \u22120.15 [RR per point, 0.97]), left atrial diameter (LASSO, 0.13 [RR per cm, 1.09]), and serum hemoglobin (LASSO, \u22120.12 [RR per g\/dL, 0.97]). At the site level, the median proportion of patients who underwent monitoring was 63% (interquartile range, 36%\u201392%). The site\u2010level proportion of patients with an implantable loop recorder was associated with greater likelihood of AF detection (RR, 3.9 [95% CI, 2.1\u20137.4]) but did not modify the trial treatment effect (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              value for interaction, 0.99).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In the ARCADIA trial, which enrolled patients with cryptogenic stroke across the United States and Canada, nearly 60% of patients underwent prolonged heart rhythm monitoring. Use of implantable loop recorders was associated with greater likelihood of AF detection.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040301","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:46:43Z","timestamp":1753789603000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Heart Rhythm Monitoring Practices, Detection of Atrial Fibrillation, and Effect of Anticoagulation in the ARCADIA Trial"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-0307","authenticated-orcid":false,"given":"Hooman","family":"Kamel","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-1156","authenticated-orcid":false,"given":"Mitchell S.V.","family":"Elkind","sequence":"additional","affiliation":[{"name":"Columbia University","place":["New York, USA"]},{"name":"Columbia University","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-7076","authenticated-orcid":false,"given":"Richard A.","family":"Kronmal","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4258-8539","authenticated-orcid":false,"given":"Rebeca","family":"Aragon Garcia","sequence":"additional","affiliation":[{"name":"Columbia University","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Plummer","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine","place":["Cincinnati, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7323-7709","authenticated-orcid":false,"given":"Joseph P.","family":"Broderick","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine","place":["Cincinnati, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-698X","authenticated-orcid":false,"given":"Qi","family":"Pauls","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina","place":["Charleston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-8474","authenticated-orcid":false,"given":"Jordan J.","family":"Elm","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina","place":["Charleston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-4196","authenticated-orcid":false,"given":"Marco R.","family":"Di Tullio","sequence":"additional","affiliation":[{"name":"Columbia University","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-8150","authenticated-orcid":false,"given":"Elsayed Z.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine","place":["Winston\u2010Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7580","authenticated-orcid":false,"given":"Jeff S.","family":"Healey","sequence":"additional","affiliation":[{"name":"McMaster University","place":["Hamilton, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-1004","authenticated-orcid":false,"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Brown Medical School","place":["Providence, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-9238","authenticated-orcid":false,"given":"Tina M.","family":"Burton","sequence":"additional","affiliation":[{"name":"Brown Medical School","place":["Providence, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-2901","authenticated-orcid":false,"given":"David L.","family":"Tirschwell","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"W. T.","family":"Longstreth","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]},{"name":"University of Washington","place":["Seattle, USA"]},{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ARCADIA Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005119"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70017-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571455"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70027-X"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.028"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493018799981"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.27188"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00326-5"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab724.2076"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.115.012195"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2022.02.006"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067512"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310234"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.040301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T12:12:35Z","timestamp":1756296755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.040301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":16,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,8,5]]}},"alternative-id":["10.1161\/JAHA.124.040301"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.040301","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,5]]},"assertion":[{"value":"2024-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040301"}}