{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:39:13Z","timestamp":1791232753943,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"\n Background<\/jats:title>\n Dapagliflozin improved cardiometabolic outcomes following myocardial infarction in patients without prior type\u20102 diabetes (T2DM) in the DAPA\u2010MI (dapagliflozin in patients with myocardial infarction) trial. The effect of glycemic status and body mass index (BMI) post\u2013myocardial infarction requires elucidation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Participants with\n T2DM<\/jats:styled-content>\n diagnosis, without baseline\n hemoglobin A1c<\/jats:styled-content>\n , or not receiving any study medication, were excluded. Eligible participants were categorized, according to baseline\n hemoglobin A1c<\/jats:styled-content>\n , as normoglycemic (<5.7% [39\u2009mmol\/mol]) or prediabetes (5.7 to <6.5% [48\u2009mmol\/mol]) and according to baseline\n BMI<\/jats:styled-content>\n (<25, 25 to <30, and \u226530\u2009kg\/m\n 2<\/jats:sup>\n ). Hazard ratios (\n HRs<\/jats:styled-content>\n ) with 95%\n CI<\/jats:styled-content>\n s and 1\u2010year Kaplan\u2013Meier rates were determined for new\u2010onset\n T2DM<\/jats:styled-content>\n (investigator\u2010reported or\n hemoglobin A1c<\/jats:styled-content>\n \u22656.5%) and New York Heart Association symptom classification during follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 4017 DAPA\u2010MI participants, 3425 were eligible. In 1926 with baseline normoglycemia, new\u2010onset T2DM occurred in 0.6% and 1.6% assigned to dapagliflozin and placebo, respectively (hazard ratio, 0.40 [95% CI, 0.15\u20131.03]); in 1499 with prediabetes at baseline, new\u2010onset T2DM occurred in 10.1% and 13.1%, respectively (hazard ratio, 0.74 [05% CI, 0.55\u20130.99];\n P<\/jats:italic>\n interaction 0.23). One\u2010year absolute risk reduction for new\u2010onset T2DM was 8.1% in those with both prediabetes and BMI \u226530. Dapagliflozin reduced the occurrence of New York Heart Association class III\u2013IV symptoms, with greater effect in those with prediabetes versus normoglycemia (\n P<\/jats:italic>\n interaction 0.009). One\u2010year absolute risk reduction for New York Heart Association class III\u2013IV symptoms was 10.0% in those with both prediabetes and BMI \u226530.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dapagliflozin reduced the occurrence of new\u2010onset T2DM following myocardial infarction, regardless of baseline hemoglobin A1c or BMI. Dapagliflozin provided greater reduction in heart failure symptom burden in those with prediabetes compared with normoglycemia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.124.040327","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:47:02Z","timestamp":1753789622000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Dapagliflozin on Cardiometabolic Outcomes After Acute Myocardial Infarction According to Baseline Glycemic Status and Body Mass Index: Subanalyses of the DAPA\u2010MI Trial"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-6229","authenticated-orcid":false,"given":"Robert F.","family":"Storey","sequence":"first","affiliation":[{"name":"University of Sheffield","place":["United Kingdom"]},{"name":"Sheffield Teaching Hospitals NHS Foundation Trust","place":["Sheffield, United 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