{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:16:54Z","timestamp":1787671014393,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Infants with congenital heart disease (CHD) may have an increased risk of seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed the US National Inpatient Sample Database (2016\u20132020). We included infants with CHD who developed seizures. We excluded premature infants &lt;34\u2009weeks and infants with central nervous system or genetic disorders. CHD was classified into shunt, cyanotic, left\u2010sided, or single ventricle lesions. We compared demographics, clinical characteristics, and outcomes between CHD infants with versus without seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Infants in the weighted sample (19\u2009089\u2009414) met our inclusion criteria. Of that group, 42.4% of patients were female and 45.8% were White. There were 417\u2009053 (2.2%) patients identified with CHD, and 47\u2009501 (0.25%) patients had at least 1 episode of seizure. Seizures occurred in 1.8% of infants with any CHD versus 0.21% of infants with no CHD (adjusted odds ratio, 5.7 [95% CI, 5.5\u20135.8];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Cyanotic CHDs were associated with the lowest incidence of seizure (1.2%) compared with shunt lesions (1.8%), left\u2010sided CHD (1.9%), or single ventricle physiology (3.2%). Factors associated with seizure in patients with CHD included male sex, maternal hypertension, sepsis, acute kidney injury, stroke, and extracorporeal membrane oxygenation support. Mortality was higher in infants with CHD who developed seizures (8.5% versus 1.1%, adjusted odds ratio 3.6 [95% CI, 3.3\u20134.0],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Infants with CHD have higher odds of experiencing seizure. Cyanotic CHD had the lowest incidence of seizure, while patients with single ventricle experienced the highest risk. Having seizures was associated with longer hospital stay and higher odds of mortality. This information may help in counseling families about the neurologic outcomes of infants with CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040465","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:57:49Z","timestamp":1761217069000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Seizures in Infants With Congenital Heart Disease: A National Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-453X","authenticated-orcid":false,"given":"Safwat","family":"Aly","sequence":"first","affiliation":[{"name":"Boston Children\u2019s Hospital","place":["Boston"]},{"name":"Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-6418","authenticated-orcid":false,"given":"Ibrahim","family":"Qattea","sequence":"additional","affiliation":[{"name":"Cleveland Clinic","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-6137","authenticated-orcid":false,"given":"Nao","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital","place":["Boston"]},{"name":"Harvard Medical School","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-6394","authenticated-orcid":false,"given":"Hany Z.","family":"Aly","sequence":"additional","affiliation":[{"name":"Cleveland Clinic","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Cleveland Clinic","place":["Cleveland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12426"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008556"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001211"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2018.11.011"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.8.773"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820904912"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.02.065"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.12.017"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-023-03315-6"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01276-3"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.1.PEDS10443"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2020.11.029"},{"key":"e_1_3_1_14_2","unstructured":"HCUP database overview. https:\/\/hcup\u2010us.ahrq.gov\/overview.jsp Accessed July 13 2024."},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015369","article-title":"International network for evaluation of outcomes in neonates (iNeo) investigators* \u2020. 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