{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:02:47Z","timestamp":1780380167899,"version":"3.54.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:sec id=\"jah311139-sec-0001\" xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Myocardial bridge (MB) is a frequent coronary artery anomaly. The aims of this study are to describe the use of antiplatelet therapy (APT) in a cohort of patients with MB and assess its impact on ischemic and bleeding events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311139-sec-0002\" xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">The RIALTO (Myocardial Bridge Evaluation Towards Personalized Medicine) registry (ID: NCT05111418) is an ambispective multicenter observational registry, enrolling patients with a clinical indication to coronary angiography and evidence of MB. The present analysis included patients with MB without any preexisting indication for APT\/anticoagulant therapy according to guidelines. Patients were categorized into 2 groups: single APT or no APT based on discharge prescriptions. The primary end point was the time to first occurrence of net adverse clinical events, defined as a composite of cardiovascular death, nonfatal myocardial infarction, unplanned or elective coronary angiography, ischemic cerebrovascular events, and any bleeding.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311139-sec-0003\" xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Out of 486 enrolled patients with MB, 221 (mean age: 60\u2009years, 66% male) were included in this analysis. One hundred and forty\u2010one patients (64%) received single APT. At a median follow\u2010up of 1661\u2009days, patients with MB receiving single APT had a higher rate of net adverse clinical events (adjusted hazard ratio [aHR], 6.2;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.03), mainly driven by a higher rate of minor bleeding events (aHR, 10.58;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.02), with no difference regarding ischemic events. Results were consistent after 1:1 propensity\u2010score matching sensitivity analyses.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec id=\"jah311139-sec-0004\" xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The prescription of single APT is common in patients with MB, and it seems to be associated with an increased risk of bleeding, in the absence of a beneficial effect on ischemic events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040513","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:10:32Z","timestamp":1751591432000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Antiplatelet Therapy in Myocardial Bridge: Insights From the RIALTO Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1587-831X","authenticated-orcid":false,"given":"Renzo","family":"Laborante","sequence":"first","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ciliberti","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8568-8130","authenticated-orcid":false,"given":"Gaetano","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Universit\u00e0 del Piemonte Orientale, Division of Cardiology, AOU Maggiore della Carit\u00e0","place":["Novara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-4548","authenticated-orcid":false,"given":"Francesco","family":"Canonico","sequence":"additional","affiliation":[{"name":"Universit\u00e0 del Piemonte Orientale, Division of Cardiology, AOU Maggiore della Carit\u00e0","place":["Novara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-4809","authenticated-orcid":false,"given":"Donato Antonio","family":"Paglianiti","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4531-9670","authenticated-orcid":false,"given":"Fabio","family":"Casamassima","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-5287","authenticated-orcid":false,"given":"Attilio","family":"Restivo","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Cicchella","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9401","authenticated-orcid":false,"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]},{"name":"Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-013X","authenticated-orcid":false,"given":"Carlo","family":"Trani","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]},{"name":"Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-422X","authenticated-orcid":false,"given":"Cristina","family":"Aurigemma","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]},{"name":"Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-182X","authenticated-orcid":false,"given":"Mattia","family":"Galli","sequence":"additional","affiliation":[{"name":"GVM Care & Research","place":["Ravenna, Italy"]},{"name":"Sapienza University of Rome","place":["Latina, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Vergallo","sequence":"additional","affiliation":[{"name":"IRCCS San Martino Hospital","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-5046","authenticated-orcid":false,"given":"Italo","family":"Porto","sequence":"additional","affiliation":[{"name":"IRCCS San Martino Hospital","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0762-5551","authenticated-orcid":false,"given":"Gianluca","family":"Anastasia","sequence":"additional","affiliation":[{"name":"IRCCS San Martino Hospital","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-1967","authenticated-orcid":false,"given":"Giuseppe Massimo","family":"Sangiorgi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-5313","authenticated-orcid":false,"given":"Gianluca","family":"Massaro","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-5232","authenticated-orcid":false,"given":"Marta","family":"Cocco","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria di Ferrara","place":["Cona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6074-2370","authenticated-orcid":false,"given":"Simone","family":"Biscaglia","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria di Ferrara","place":["Cona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5150-188X","authenticated-orcid":false,"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria di Ferrara","place":["Cona, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Andreini","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Galeazzi Sant\u2019Ambrogio","place":["Milan, Italy"]},{"name":"University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Leone","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart","place":["Rome, Italy"]},{"name":"Gemelli Isola Hospital","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-411X","authenticated-orcid":false,"given":"Filippo","family":"Crea","sequence":"additional","affiliation":[{"name":"Gemelli Isola Hospital","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5404-3968","authenticated-orcid":false,"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 del Piemonte Orientale, Division of Cardiology, AOU Maggiore della Carit\u00e0","place":["Novara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-8330","authenticated-orcid":false,"given":"Domenico","family":"D'Amario","sequence":"additional","affiliation":[{"name":"Universit\u00e0 del Piemonte Orientale, Division of Cardiology, AOU Maggiore della Carit\u00e0","place":["Novara, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"RIALTO registry investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.970422"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.859"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4950260806"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-18-00920"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.117.006247"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00588-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-21-00904"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0225-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.04.051"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz046"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805819"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy813"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144148"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suac059"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.699579"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2308286"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-09-0648"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2019.10.012"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.08.041"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13355"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)31924-x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.04.028"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20578"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.501"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-20-01197"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-1019-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1009475"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.014611"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5034"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249736"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.14.2093"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23697"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2012.10.002"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.01.041"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2014.07.012"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.124.040513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T10:11:14Z","timestamp":1752660674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.124.040513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":35,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7,15]]}},"alternative-id":["10.1161\/JAHA.124.040513"],"URL":"https:\/\/doi.org\/10.1161\/jaha.124.040513","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2024-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e040513"}}