{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:49:22Z","timestamp":1784562562396,"version":"3.55.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients with both peripheral artery disease (PAD) and coronary artery disease are at heightened risk for adverse cardiovascular outcomes. Although long\u2010term risk has been well documented, contemporary in\u2010hospital outcomes for patients with PAD presenting with acute myocardial infarction (AMI) are less well characterized.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We analyzed 493\u2009740 AMI hospitalizations from 670 US sites in the NCDR (National Cardiovascular Data Registry) Chest Pain\u2013MI Registry between January 2019 and March 2023. Primary outcomes were in\u2010hospital mortality and major bleeding; secondary end points included cardiac arrest, cardiogenic shock, heart failure, stroke, and new dialysis initiation. Subgroup analyses were conducted by age, sex, race, AMI type, revascularization status, and extent of coronary disease. We used the NCDR validated risk model for multivariable adjustment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">PAD was present in 36\u2009274 patients with AMI (7.4%). In\u2010hospital mortality was significantly higher in patients with PAD compared with those without (8.23% versus 4.87%; adjusted odds ratio [aOR], 1.25 [95% CI, 1.19\u20131.31]). Increased mortality persisted across age groups (&lt;65 years: aOR, 1.42; \u226565 years: aOR, 1.18) and AMI type (non\u2013ST\u2010segment\u2013elevation MI: aOR, 1.14;\u00a0ST\u2010segment\u2013elevation MI: aOR, 1.46), with significant interactions by both age and AMI type. Among revascularized patients, mortality was elevated in those with PAD (aOR, 1.49). PAD was associated with increased rates of major bleeding (aOR, 1.23), particularly among revascularized patients (aOR, 1.31), as well as cardiac arrest, shock, heart failure, stroke, and new dialysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">PAD was independently associated with markedly worse in\u2010hospital outcomes in AMI, highlighting the need for risk mitigation strategies in this high\u2010risk population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040526","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:14:36Z","timestamp":1749626076000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-5942","authenticated-orcid":false,"given":"Jason","family":"Gusdorf","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-9110","authenticated-orcid":false,"given":"Kamil F.","family":"Faridi","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute","place":["Durham, 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