{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:48:53Z","timestamp":1791528533498,"version":"4.3.4"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Human cytomegalovirus is a herpes virus that affects most individuals globally and may increase the risk of cardiovascular disease. Whether cytomegalovirus influences outcomes after ST\u2010segment\u2013elevation myocardial infarction (STEMI) is unknown. Our objective was to investigate the association between latent cytomegalovirus infection and outcomes after STEMI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">This study includes 354 patients with STEMI who were recruited to T\u2010TIME (A Trial of Low\u2010Dose Adjunctive Alteplase During Primary PCI) and had blood samples cryopreserved. Participants underwent immediate percutaneous coronary intervention, serial cardiovascular magnetic resonance imaging at 2 to 7\u2009days and 3\u2009months post\u2010STEMI, and assessment of health\u2010related quality of life with the EuroQol 5\u2010Dimension visual analog scale. Cytomegalovirus Ig (immunoglobulin) G titer was measured in cryopreserved baseline samples from each patient. Results were adjusted for age and other possible confounders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              One hundred seventy\u2010five patients (49.4%) were cytomegalovirus IgG titer\u2010negative, 89 (25.1%) were low\u2010positive, and 90 (25.4%) were high\u2010positive. Patients who were cytomegalovirus\u2010positive were older (62.5 versus 58.7\u2009years of age) and more likely to be non\u2010White (6.7% versus 2.3%). Myocardial reperfusion, measured by ST\u2010segment resolution, was less successful in patients who were cytomegalovirus\u2010positive (38.7% resolution versus 48.4%; adjusted\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.032). Left ventricular ejection fraction was lower in patients who were cytomegalovirus\u2010positive in the first week (42.6% versus 45.3%; adjusted\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.006) and at 3\u2009months (47.8% versus 49.7%; adjusted\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.033). Over 3\u2009months, patients who were cytomegalovirus\u2010positive had less improvement in health\u2010related quality of life (change in EuroQol 5\u2010Dimension visual analog scale: +3.38 versus +9.93; adjusted\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients who are cytomegalovirus\u2010positive with STEMI have impaired reperfusion, reduced left ventricular function, and less improvement in health\u2010related quality of life over 3\u2009months.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.124.040584","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:26:53Z","timestamp":1754998013000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST\u2010Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-0373","authenticated-orcid":false,"given":"Luke","family":"Spray","sequence":"first","affiliation":[{"name":"Newcastle University","place":["Newcastle Upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"McIntosh","sequence":"additional","affiliation":[{"name":"University of Glasgow","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-1811","authenticated-orcid":false,"given":"Peter J.","family":"McCartney","sequence":"additional","affiliation":[{"name":"Golden Jubilee National Hospital","place":["Clydebank, United 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