{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:58Z","timestamp":1788480598669,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Catheter ablation is a first\u2010line therapy for atrial fibrillation (AF). We evaluated the impact of obstructive sleep apnea (OSA) on arrhythmia and postablation quality\u2010of\u2010life outcomes among AF subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Consecutive patients undergoing AF ablation (2013\u20132022) at a tertiary center were enrolled and assessed for arrhythmia recurrence over 3\u2010year follow\u2010up. A subset of patients enrolled in an automated patient\u2010reported outcomes platform were assessed for quality of life, including Atrial Fibrillation Severity Score and AF burden (AF duration and frequency scores).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 7020 patients were included: 3380 with paroxysmal AF (PAF) and 3640 with persistent AF (PersAF), of whom 729 and 943 had OSA, respectively (PAF: age, 66.5\u00b110\u2009years [69% men]; PersAF: age, 66.1\u00b19\u2009years [76% men]). Unlike patients with PersAF, those with PAF and OSA had higher AF recurrence (PAF: no OSA=70% versus OSA=64% [\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01]; PersAF: no OSA=57% versus OSA=60% [\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.24]). Baseline OSA was independently associated with a 30% increased AF recurrence risk (hazard ratio, 1.30;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) among patients with PAF, but not among patients with PersAF. Significant improvement in 1\u2010year postablation quality of life was noted in both groups irrespective of OSA (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001 for all comparisons): (1) median AF symptom severity (PAF: no OSA 10\u21922, OSA 12\u21924; PersAF: 12\u21924 in both groups); and (2) median AF duration (PAF: 6.25\u21920 in both groups; PersAF: 10\u21920 in both groups); median AF frequency (PAF: 6\u21920 in both groups; PersAF: 9\u21920 in both groups).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Baseline OSA was associated with an increased AF recurrence risk in patients with PAF, but not in those with PersAF. Catheter ablation resulted in improvement of quality\u2010of\u2010life metrics irrespective of baseline OSA among AF subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.124.040631","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:25:36Z","timestamp":1760444736000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Obstructive Sleep Apnea on Arrhythmia and Quality\u2010of\u2010Life Outcomes After Catheter Ablation of Atrial Fibrillation"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-8252","authenticated-orcid":false,"given":"Lorenzo","family":"Braghieri","sequence":"first","affiliation":[{"name":"Cleveland Clinic","place":["Cleveland, 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